Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU134653" target="_blank" >RIV/00216305:26210/19:PU134653 - isvavai.cz</a>

Výsledek na webu

<a href="http://cas.icpf.cas.cz/download/Sbornik_VKCAS_2019.pdf" target="_blank" >http://cas.icpf.cas.cz/download/Sbornik_VKCAS_2019.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Popis výsledku v původním jazyce

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

Název v anglickém jazyce

Measurement of orientation of fibres in a simplified replica of human trachea under steady conditions

Popis výsledku anglicky

Although inhalable fibres are mostly regarded as dangerous and harmful because they are mostly associated with asbestos, several authors have recommended the application of tubular or fibrous particles for drug delivery. Chan and Gonda (1989) were among the first who ventured to enter the unexplored realm of pharmaceutically usable fibres. They prepared fibres from cromoglycic acid which has low solubility in water and therefore should not experience significant hygroscopic growth in the airways. Johnson et al. (2000) suggested packing tubular shell particles with an Active Pharmaceutical Ingredient (API) to maximise the per particle dose while targeting distal regions of lungs. Martin and Finlay (2008) have demonstrated the applicability of magnetic field targeting of magnetite-loaded fibres for efficient delivery to specified locations in lungs and encouraged other researchers to develop formulations with fibrous aerosol incorporating chemotherapeutic agents for the treatment of lung cancer.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20301 - Mechanical engineering

Projekt

<a href="/cs/project/GA18-25618S" target="_blank" >GA18-25618S: Výzkum účinku nestacionárního proudění na transport vláken v postupně se větvících minikanálech</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů