Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F19%3APU137612" target="_blank" >RIV/00216305:26210/19:PU137612 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27230/19:10242474

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1350453319300876?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.medengphy.2019.04.011" target="_blank" >10.1016/j.medengphy.2019.04.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

Popis výsledku v původním jazyce

Peak stress in the fibrous cap of atherosclerotic plaque is largely determined by the cap thickness which cannot be accurately estimated in vivo. This parametric study investigates idealized atherosclerotic plaque geometries. Finite element modeling is applied to search for larger morphological features associated with high cap stresses. By varying seven geometrical and two loading parameters, 100 3D model geometries of atherosclerotic plaques in common iliac artery were generated. In each model peak cap stress was cal- culated, and statistical comparison of the geometries generating the highest and lowest peak cap stresses was performed. The analysis showed that, compared to geometries generating the lowest stresses, those with high peak cap stress had a significantly lower cap thickness, higher stenosis ratio, lower relative lipid core volume, and cap shoulder radius larger than lipid core radius. High cap stress was observed for cap thicknesses up to 0.13 mm. It can be concluded that vulnerable plaques contain thin fibrous cap, large stenosis ratio and only moderate small-radius lipid core which reaches the shoulder region of the fibrous cap. (C) 2019 IPEM. Published by Elsevier Ltd. All rights reserved.

Název v anglickém jazyce

Moderate thickness of lipid core in shoulder region of atherosclerotic plaque determines vulnerable plaque - A parametric study

Popis výsledku anglicky

Peak stress in the fibrous cap of atherosclerotic plaque is largely determined by the cap thickness which cannot be accurately estimated in vivo. This parametric study investigates idealized atherosclerotic plaque geometries. Finite element modeling is applied to search for larger morphological features associated with high cap stresses. By varying seven geometrical and two loading parameters, 100 3D model geometries of atherosclerotic plaques in common iliac artery were generated. In each model peak cap stress was cal- culated, and statistical comparison of the geometries generating the highest and lowest peak cap stresses was performed. The analysis showed that, compared to geometries generating the lowest stresses, those with high peak cap stress had a significantly lower cap thickness, higher stenosis ratio, lower relative lipid core volume, and cap shoulder radius larger than lipid core radius. High cap stress was observed for cap thicknesses up to 0.13 mm. It can be concluded that vulnerable plaques contain thin fibrous cap, large stenosis ratio and only moderate small-radius lipid core which reaches the shoulder region of the fibrous cap. (C) 2019 IPEM. Published by Elsevier Ltd. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/GA18-13663S" target="_blank" >GA18-13663S: Výpočtové modelování rizika ruptury aterosklerotických plátů v krčních tepnách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MEDICAL ENGINEERING & PHYSICS

ISSN

1350-4533

e-ISSN

1873-4030

Svazek periodika

69

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

140-146

Kód UT WoS článku

000519204300017

EID výsledku v databázi Scopus

2-s2.0-85066333070