The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F20%3APU136810" target="_blank" >RIV/00216305:26210/20:PU136810 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14160/20:00118115

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jaerosci.2020.105582" target="_blank" >10.1016/j.jaerosci.2020.105582</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

Popis výsledku v původním jazyce

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively. There was a good agreement between the experimental and simulation deposition results also in the different predefined sections of the airways. Present pilot study proved that lobar flow redistribution due to severe asthma significantly modified the deposition distribution of micro-particles. Althoug

Název v anglickém jazyce

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

Popis výsledku anglicky

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively. There was a good agreement between the experimental and simulation deposition results also in the different predefined sections of the airways. Present pilot study proved that lobar flow redistribution due to severe asthma significantly modified the deposition distribution of micro-particles. Althoug

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20402 - Chemical process engineering

Projekt

<a href="/cs/project/GA18-25618S" target="_blank" >GA18-25618S: Výzkum účinku nestacionárního proudění na transport vláken v postupně se větvících minikanálech</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF AEROSOL SCIENCE

ISSN

0021-8502

e-ISSN

1879-1964

Svazek periodika

147

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

1-16

Kód UT WoS článku

000540032700004

EID výsledku v databázi Scopus

2-s2.0-85085237245