FINITE ELEMENT MODELS OF MECHANICAL BEHAVIOUR OF ENDOTHELIAL CELLS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F20%3APU138085" target="_blank" >RIV/00216305:26210/20:PU138085 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.21495/5896-3-222" target="_blank" >http://dx.doi.org/10.21495/5896-3-222</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21495/5896-3-222" target="_blank" >10.21495/5896-3-222</a>

Jazyk výsledku

angličtina

Název v původním jazyce

FINITE ELEMENT MODELS OF MECHANICAL BEHAVIOUR OF ENDOTHELIAL CELLS

Popis výsledku v původním jazyce

Recently hybrid models of the endothelial cell were created by using the bendo-tensegrity concept to complete the continuum parts of the cell with an adequate cytoskeleton model. The proposed model of endothelial cell includes a network of actin filaments (AFs) as tension supporting cables and microtubules (MTs) as bended beams supporting primarily compression. It is created by adopting the geometrical shape of a short hexagonal prism with its 12 vertices that results in a nearly isotropic behaviour of the model without a preferred orientation. To achieve the synergistic effect of cytoskeletal components, the elements representing AFs, MTs, and Intermediate filaments (IFs) are sharing the same end nodes (representing focal adhesions) with the cell membrane (CM). The AFs are prestressed (i.e. stressed without application of external load), which is essential for the cell shape stability, while the IFs are wavy, thus not bearing load until straightened. The objective is to create different FE models of endothelial cells which will be used to simulate mechanical responses of the cell under different loading conditions. Endothelial cell dysfunction has been linked to atherosclerosis through their response to mechanical loads, especially hemodynamic forces.

Název v anglickém jazyce

FINITE ELEMENT MODELS OF MECHANICAL BEHAVIOUR OF ENDOTHELIAL CELLS

Popis výsledku anglicky

Recently hybrid models of the endothelial cell were created by using the bendo-tensegrity concept to complete the continuum parts of the cell with an adequate cytoskeleton model. The proposed model of endothelial cell includes a network of actin filaments (AFs) as tension supporting cables and microtubules (MTs) as bended beams supporting primarily compression. It is created by adopting the geometrical shape of a short hexagonal prism with its 12 vertices that results in a nearly isotropic behaviour of the model without a preferred orientation. To achieve the synergistic effect of cytoskeletal components, the elements representing AFs, MTs, and Intermediate filaments (IFs) are sharing the same end nodes (representing focal adhesions) with the cell membrane (CM). The AFs are prestressed (i.e. stressed without application of external load), which is essential for the cell shape stability, while the IFs are wavy, thus not bearing load until straightened. The objective is to create different FE models of endothelial cells which will be used to simulate mechanical responses of the cell under different loading conditions. Endothelial cell dysfunction has been linked to atherosclerosis through their response to mechanical loads, especially hemodynamic forces.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA18-13663S" target="_blank" >GA18-13663S: Výpočtové modelování rizika ruptury aterosklerotických plátů v krčních tepnách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Engineering Mechanics 2020

ISBN

978-80-214-5896-3

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

222-225

Název nakladatele

Neuveden

Místo vydání

neuveden

Místo konání akce

Online

Datum konání akce

24. 11. 2020

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000667956100048