IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F20%3APU138087" target="_blank" >RIV/00216305:26210/20:PU138087 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

Popis výsledku v původním jazyce

Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.

Název v anglickém jazyce

IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

Popis výsledku anglicky

Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA18-13663S" target="_blank" >GA18-13663S: Výpočtové modelování rizika ruptury aterosklerotických plátů v krčních tepnách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů