In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F23%3APU147252" target="_blank" >RIV/00216305:26210/23:PU147252 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10455430 RIV/70883521:28610/23:63566558

Výsledek na webu

<a href="https://www.mdpi.com/2075-4442/11/1/12" target="_blank" >https://www.mdpi.com/2075-4442/11/1/12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/lubricants11010012" target="_blank" >10.3390/lubricants11010012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Popis výsledku v původním jazyce

Degradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface.

Název v anglickém jazyce

In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Popis výsledku anglicky

Degradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20301 - Mechanical engineering

Projekt

<a href="/cs/project/GA20-00483S" target="_blank" >GA20-00483S: Vliv viskosuplementace kloubní kapaliny na tření a mazání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Lubricants

ISSN

2075-4442

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

15

Strana od-do

„“-„“

Kód UT WoS článku

000915175500001

EID výsledku v databázi Scopus

2-s2.0-85146757532