In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F24%3APU151083" target="_blank" >RIV/00216305:26210/24:PU151083 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/24:00080560 RIV/00216224:14110/24:00139738

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0169260724000129" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169260724000129</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmpb.2024.108016" target="_blank" >10.1016/j.cmpb.2024.108016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs

Popis výsledku v původním jazyce

Background and objectives: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. Methods: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. Results: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of areaaveraged TAWSS related to the old flow waveform is much more pronounced (2.5 divided by 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. Conclusions: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.

Název v anglickém jazyce

In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs

Popis výsledku anglicky

Background and objectives: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. Methods: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. Results: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of areaaveraged TAWSS related to the old flow waveform is much more pronounced (2.5 divided by 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. Conclusions: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/GA21-21935S" target="_blank" >GA21-21935S: Výpočtové modelování pulzačního proudění v poddajných trubicích s aplikací na tandemovou stenózu karotidy</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

ISSN

0169-2607

e-ISSN

1872-7565

Svazek periodika

245

Číslo periodika v rámci svazku

2024

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

„108016-1“-„108016-10“

Kód UT WoS článku

001166225300001

EID výsledku v databázi Scopus

2-s2.0-85183468867