Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F25%3APU156191" target="_blank" >RIV/00216305:26210/25:PU156191 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0316719</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0316719" target="_blank" >10.1371/journal.pone.0316719</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Popis výsledku v původním jazyce

Background and objective The use of bone allograft reconstructions after tumor resection can introduce significant complications. Stable fixation is required to decrease the incidence of mechanical complications of segmental bone allografts. The purpose of the present study is to compare plating fixation methods of diaphyseal allografts after intercalary resection of the femur. Methods We created four defined fixation models using plates and/or intramedullary polymethylmethacrylate (PMMA) to simulate typical bone tumor resection with intercalary allograft reconstruction. One angularly stable plate (DFP) with 13 locking screws and fresh frozen allografts (labeled "I") were used for bone reconstruction. Three modified reconstructions were created: "II" included a supplementary plate (SP) with four locking screws, "III" was augmented with intramedullary PMMA in the allograft, and "IV" combined intramedullary PMMA and both plates. We applied a load model that simulates partial weight bearing on the lower limb to simulate the load during postoperative rehabilitation. Results The highest stress in the DFP occurred at the allograft-bone transition, with variant IV reaching 297 MPa. PMMA augmentation reduced median interfragmentary motion (IFM) and sliding distances, with variant III achieving the lowest distal sliding distance (0.9 mu m) in the distal area. Supplementary plate fixation reduced maximal and median proximal IFM distances (86.9 mu m in variant II vs. 116.0 mu m in variant I) but increased sliding distances (23.7 mu m in variant II vs. 0.6 mu m in variant I). Conclusions PMMA augmentation reduces IFM and sliding distances, enhancing rigidity, particularly in the distal area. Supplementary plate fixation decreases IFM distances in the proximal area but increases sliding distances in the same region. Variants III and IV demonstrate lower IFM and sliding distances in the distal area overall. Variant III shows very low sliding distances in both distal and proximal

Název v anglickém jazyce

Computational modeling of bone allograft reconstruction following femoral shaft tumor resection: Investigating the impact of supplementary plate fixation

Popis výsledku anglicky

Background and objective The use of bone allograft reconstructions after tumor resection can introduce significant complications. Stable fixation is required to decrease the incidence of mechanical complications of segmental bone allografts. The purpose of the present study is to compare plating fixation methods of diaphyseal allografts after intercalary resection of the femur. Methods We created four defined fixation models using plates and/or intramedullary polymethylmethacrylate (PMMA) to simulate typical bone tumor resection with intercalary allograft reconstruction. One angularly stable plate (DFP) with 13 locking screws and fresh frozen allografts (labeled "I") were used for bone reconstruction. Three modified reconstructions were created: "II" included a supplementary plate (SP) with four locking screws, "III" was augmented with intramedullary PMMA in the allograft, and "IV" combined intramedullary PMMA and both plates. We applied a load model that simulates partial weight bearing on the lower limb to simulate the load during postoperative rehabilitation. Results The highest stress in the DFP occurred at the allograft-bone transition, with variant IV reaching 297 MPa. PMMA augmentation reduced median interfragmentary motion (IFM) and sliding distances, with variant III achieving the lowest distal sliding distance (0.9 mu m) in the distal area. Supplementary plate fixation reduced maximal and median proximal IFM distances (86.9 mu m in variant II vs. 116.0 mu m in variant I) but increased sliding distances (23.7 mu m in variant II vs. 0.6 mu m in variant I). Conclusions PMMA augmentation reduces IFM and sliding distances, enhancing rigidity, particularly in the distal area. Supplementary plate fixation decreases IFM distances in the proximal area but increases sliding distances in the same region. Variants III and IV demonstrate lower IFM and sliding distances in the distal area overall. Variant III shows very low sliding distances in both distal and proximal

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLOS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

20

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

„“-„“

Kód UT WoS článku

001435274300064

EID výsledku v databázi Scopus

2-s2.0-85217027243