Návrh elektrochemického sensoru pro mikroanalýzu mědi v biologických vzorcích

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F08%3APU77883" target="_blank" >RIV/00216305:26220/08:PU77883 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

Popis výsledku v původním jazyce

There have been published several papers on voltammetric ultra-trace determination of some nucleic bases in the presence of Cu(II) using a mercury electrode or solid amalgam electrodes. Carbon electrodes can be used for the same purposes. The aim of thiswork was to employ the behaviour of purines in the presence of Cu(II) to determine these metal ions. Primarily we aimed on investigation of basic electrochemical behaviour of detection copper at hanging mercury drop and carbon paste electrodes by usingof cyclic and differential pulse voltammetry. Thanks to formation of the complex adenine-Cu(II) under the specific conditions the peak of this complex was measured at -0.6 V. The detection limit (3 S/N) for Cu(II) ions was estimated as 5 nM. By using ofthis approach we were able to determine the content of copper in animal tissues even at tens of nM. Moreover we utilized suggested approach to monitor the level of copper ions in samples of blood serum of patients with metabolic disorder.

Název v anglickém jazyce

Suggestion of electrochemical sensors for microanalysis of content of copper in biological samples

Popis výsledku anglicky

There have been published several papers on voltammetric ultra-trace determination of some nucleic bases in the presence of Cu(II) using a mercury electrode or solid amalgam electrodes. Carbon electrodes can be used for the same purposes. The aim of thiswork was to employ the behaviour of purines in the presence of Cu(II) to determine these metal ions. Primarily we aimed on investigation of basic electrochemical behaviour of detection copper at hanging mercury drop and carbon paste electrodes by usingof cyclic and differential pulse voltammetry. Thanks to formation of the complex adenine-Cu(II) under the specific conditions the peak of this complex was measured at -0.6 V. The detection limit (3 S/N) for Cu(II) ions was estimated as 5 nM. By using ofthis approach we were able to determine the content of copper in animal tissues even at tens of nM. Moreover we utilized suggested approach to monitor the level of copper ions in samples of blood serum of patients with metabolic disorder.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/KAN208130801" target="_blank" >KAN208130801: Nové konstrukce a využití nanobiosenzorů a nanosenzorů v medicíně (NANOSEMED)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Seventh IEEE Conference on SENSORS

ISSN

1930-0395

e-ISSN

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Svazek periodika

2008

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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