Cell toxicity and preparation of streptavidin-modified iron nanoparticles and glutathione-modified cadmium-based quantum dots

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F10%3APU88630" target="_blank" >RIV/00216305:26220/10:PU88630 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/10:00002667

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cell toxicity and preparation of streptavidin-modified iron nanoparticles and glutathione-modified cadmium-based quantum dots

Popis výsledku v původním jazyce

This paper is focused on the investigation of conjugate nanostructures consisting of superparamagnetic nanoparticles (NPs) and CdSe/CdS quantum dots (QDs) with core/shell structure. In the first step, we prepared streptavidin (STP) conjugated Fe2O3 magnetic particles. The next stage was preparation of QDs using method based on surface modification of hydrophobic core/shell CdSe/CdS with biotinylated glutathione. Glutathione (GSH) belongs to the most abundant peptides in organisms maintaining redox status, which, from the particle point of view, makes the QDs water-soluble and stabilized in aqueous solution. Biotin molecule is known for its excellent affinity to streptavidin and hence allows the conjugation of both nanostructures (magnetic and light-emitting). We tested the influence of both prepared nanostructures on growth and viability of fibroblasts and BY-2 tobacco cells, respectively. NPs-STP and QDs-GSH may not pose a threat to cells, but non-modified nanoparticles and QDs withou

Název v anglickém jazyce

Cell toxicity and preparation of streptavidin-modified iron nanoparticles and glutathione-modified cadmium-based quantum dots

Popis výsledku anglicky

This paper is focused on the investigation of conjugate nanostructures consisting of superparamagnetic nanoparticles (NPs) and CdSe/CdS quantum dots (QDs) with core/shell structure. In the first step, we prepared streptavidin (STP) conjugated Fe2O3 magnetic particles. The next stage was preparation of QDs using method based on surface modification of hydrophobic core/shell CdSe/CdS with biotinylated glutathione. Glutathione (GSH) belongs to the most abundant peptides in organisms maintaining redox status, which, from the particle point of view, makes the QDs water-soluble and stabilized in aqueous solution. Biotin molecule is known for its excellent affinity to streptavidin and hence allows the conjugation of both nanostructures (magnetic and light-emitting). We tested the influence of both prepared nanostructures on growth and viability of fibroblasts and BY-2 tobacco cells, respectively. NPs-STP and QDs-GSH may not pose a threat to cells, but non-modified nanoparticles and QDs withou

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JB - Senzory, čidla, měření a regulace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Procedia Engineering

ISSN

1877-7058

e-ISSN

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Svazek periodika

2010

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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