Effect Of Cognitive Stimulation On Hippocampal Ripples In Epileptic Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F13%3APU105035" target="_blank" >RIV/00216305:26220/13:PU105035 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jns.2013.07.131" target="_blank" >http://dx.doi.org/10.1016/j.jns.2013.07.131</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2013.07.131" target="_blank" >10.1016/j.jns.2013.07.131</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect Of Cognitive Stimulation On Hippocampal Ripples In Epileptic Patients

Popis výsledku v původním jazyce

Interictal HFOs (ripples and fast ripples) have been repeatedly identified in recordings from depth macroelectrodes in epileptics. In contrast to fast ripples, which are believed to reflect the neuronal substrates of epileptogenicity, ripples are considered to be a signature of both normal and epileptic brain processes. The differentiation of physiological and epileptic ripples in intracranial recordings remains unavailable. We analyzed SEEG recordings in seven patients with intractable partial seizures in whom hippocampal activity was recorded in resting state and subsequently during simple cognitive task with randomly presented frequent and rare visual stimuli. Using automated detection of ripples based on length of power envelope, we analyzed potentia l differences in ripple rate (RR) in the cognitive vs. resting period, within epileptic (EH) and nonepileptic hippocampi (NH). Further direct impact of cognitive stimuli on ripples (immediately after the stimulus) was investigated. Ripples have been detected within hippocampal recordings in all the investigated subjects. Mean RR in resting periods was 11.36 +/- 8.34/min within EH, and 10.13 +/- 8.75/min within NH. In the cognitive task periods mean RR within EH and NH decreased to 7.16 +/-5.75/min, and 8.75 +/- 7.69/min respectively. The reduction of RR during cognitive stimulation was significant in EH, but not in NH. Interestingly we observed a transient suppression of ripples in both EH (slight) and NH (significant) in the first second after the stimuli onset, followed by a significant increase in RR for both EH and NH. Our results point to different reactivity of ripples within EH and NH to the cognitive stimulation.

Název v anglickém jazyce

Effect Of Cognitive Stimulation On Hippocampal Ripples In Epileptic Patients

Popis výsledku anglicky

Interictal HFOs (ripples and fast ripples) have been repeatedly identified in recordings from depth macroelectrodes in epileptics. In contrast to fast ripples, which are believed to reflect the neuronal substrates of epileptogenicity, ripples are considered to be a signature of both normal and epileptic brain processes. The differentiation of physiological and epileptic ripples in intracranial recordings remains unavailable. We analyzed SEEG recordings in seven patients with intractable partial seizures in whom hippocampal activity was recorded in resting state and subsequently during simple cognitive task with randomly presented frequent and rare visual stimuli. Using automated detection of ripples based on length of power envelope, we analyzed potentia l differences in ripple rate (RR) in the cognitive vs. resting period, within epileptic (EH) and nonepileptic hippocampi (NH). Further direct impact of cognitive stimuli on ripples (immediately after the stimulus) was investigated. Ripples have been detected within hippocampal recordings in all the investigated subjects. Mean RR in resting periods was 11.36 +/- 8.34/min within EH, and 10.13 +/- 8.75/min within NH. In the cognitive task periods mean RR within EH and NH decreased to 7.16 +/-5.75/min, and 8.75 +/- 7.69/min respectively. The reduction of RR during cognitive stimulation was significant in EH, but not in NH. Interestingly we observed a transient suppression of ripples in both EH (slight) and NH (significant) in the first second after the stimuli onset, followed by a significant increase in RR for both EH and NH. Our results point to different reactivity of ripples within EH and NH to the cognitive stimulation.

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Epilepsia

ISBN

—

ISSN

1300-1817

e-ISSN

—

Počet stran výsledku

1

Strana od-do

1-1

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Montreal

Datum konání akce

23. 6. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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