Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements

Popis výsledku v původním jazyce

Doxorubicin is a planar aromatic molecule and it is commonly used in cancer chemotherapy. In this study, we compared nanostructured electrodes with gold nanocolumns and flat gold electrodes by measurements with doxorubicin. Nanostructured electrodes were fabricated by electrochemical anodic oxidation when the aluminium layer was transformed to the porous alumina layer. Then gold material was deposited into the pores. After removal of aluminium template the nanostructured surface made of ordered gold nanocolumns on metal underlay was obtained. Flat gold electrodes were fabricated by evaporation of gold layer to the silicon substrate. After that, all electrodes were characterized by electrochemical impedance spectroscopy and then the detection of doxorubicin was studied by differential pulse voltammetry. According to the impedance spectroscopy measurements a bigger electroactive area for nanostructured electrodes was proved. The gold nanocolumns have been found as a significant factor in increasing of electrodes active area. This fact is very important for sensors sensitivity. Fabricated electrodes were successfully used for determination of doxorubicin. Doxorubicin oxidation peak was observed at a potential - 0.6 V.

Název v anglickém jazyce

Comparison of gold nanostructured electrode and flat gold electrode on doxorubicin measurements

Popis výsledku anglicky

Doxorubicin is a planar aromatic molecule and it is commonly used in cancer chemotherapy. In this study, we compared nanostructured electrodes with gold nanocolumns and flat gold electrodes by measurements with doxorubicin. Nanostructured electrodes were fabricated by electrochemical anodic oxidation when the aluminium layer was transformed to the porous alumina layer. Then gold material was deposited into the pores. After removal of aluminium template the nanostructured surface made of ordered gold nanocolumns on metal underlay was obtained. Flat gold electrodes were fabricated by evaporation of gold layer to the silicon substrate. After that, all electrodes were characterized by electrochemical impedance spectroscopy and then the detection of doxorubicin was studied by differential pulse voltammetry. According to the impedance spectroscopy measurements a bigger electroactive area for nanostructured electrodes was proved. The gold nanocolumns have been found as a significant factor in increasing of electrodes active area. This fact is very important for sensors sensitivity. Fabricated electrodes were successfully used for determination of doxorubicin. Doxorubicin oxidation peak was observed at a potential - 0.6 V.

Druh

D - Stať ve sborníku

CEP obor

JB - Senzory, čidla, měření a regulace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Conference Proceedings 5th International Conference NANOCON 2013

ISBN

978-80-87294-47-5

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

215-219

Název nakladatele

Tanger, Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

16. 10. 2013

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000352070900036