Spectral and electrochemical analysis of miR-34a-5p

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU117267" target="_blank" >RIV/00216305:26220/15:PU117267 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Spectral and electrochemical analysis of miR-34a-5p

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are small (22 nt), single-stranded, non-coding RNAs known as regulators of gene expression at the mRNA level. Their impact on the final translation product is significant, therefore it is suitable to study them as biomarkers of variousdiseases namely diabetes, cardiovascular, neurodegenerative, viral diseases and cancer [1]. Our attention was aimed at the research of miR-34a-5p related to head and neck cancer (HNC) and also prostate cancer (PCa) where we obtained significant differences in miR-34a-5p expression status between health controls and patients with PCa. This miRNA, belonging to the miR-34 family is directly linked to p53 and Wnt pathways [2]. The tight connection between loss of tumor suppressor function and activation ofoncogenic signaling has been proven for this miRNA. Beside the classical molecular?biological methods studying miRNAs, such as PCR, Northern Blotting (NB), microarrays technologies, new biophysical approaches were applied [3]. The result

Název v anglickém jazyce

Spectral and electrochemical analysis of miR-34a-5p

Popis výsledku anglicky

MicroRNAs (miRNAs) are small (22 nt), single-stranded, non-coding RNAs known as regulators of gene expression at the mRNA level. Their impact on the final translation product is significant, therefore it is suitable to study them as biomarkers of variousdiseases namely diabetes, cardiovascular, neurodegenerative, viral diseases and cancer [1]. Our attention was aimed at the research of miR-34a-5p related to head and neck cancer (HNC) and also prostate cancer (PCa) where we obtained significant differences in miR-34a-5p expression status between health controls and patients with PCa. This miRNA, belonging to the miR-34 family is directly linked to p53 and Wnt pathways [2]. The tight connection between loss of tumor suppressor function and activation ofoncogenic signaling has been proven for this miRNA. Beside the classical molecular?biological methods studying miRNAs, such as PCR, Northern Blotting (NB), microarrays technologies, new biophysical approaches were applied [3]. The result

Druh

O - Ostatní výsledky

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED2.1.00%2F03.0072" target="_blank" >ED2.1.00/03.0072: Centrum senzorických, informačních a komunikačních systémů (SIX)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů