Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU118945" target="_blank" >RIV/00216305:26220/16:PU118945 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

Popis výsledku v původním jazyce

The number of drug-resistant strains of Borrelia burgdorferi necessitated the identification of potential drug targets specific to the strain of interest. The chromosomal and plasmid genes of B. burgdorferistrain B31 were compared with erythromycin-resistant B. burgdorferistrain N40 to find common (core) and unique (strain-specific) genes in present study. In silicoanalysis of genomic data showed total number of unique genes higher in strain N40. The presence of higher number of unique genes in N40 signifies their role in drug resistance mechanism. Furthermore, human proteome was compared with proteome of these strains to find target protein specific to the strain of interest and not present in host. In conclusion, identification of unique genes in these strains provided on differences in drug resistance potential.

Název v anglickém jazyce

Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

Popis výsledku anglicky

The number of drug-resistant strains of Borrelia burgdorferi necessitated the identification of potential drug targets specific to the strain of interest. The chromosomal and plasmid genes of B. burgdorferistrain B31 were compared with erythromycin-resistant B. burgdorferistrain N40 to find common (core) and unique (strain-specific) genes in present study. In silicoanalysis of genomic data showed total number of unique genes higher in strain N40. The presence of higher number of unique genes in N40 signifies their role in drug resistance mechanism. Furthermore, human proteome was compared with proteome of these strains to find target protein specific to the strain of interest and not present in host. In conclusion, identification of unique genes in these strains provided on differences in drug resistance potential.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů