Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F16%3APU120838" target="_blank" >RIV/00216305:26220/16:PU120838 - isvavai.cz</a>

Výsledek na webu

<a href="https://ieeexplore.ieee.org/document/7868926" target="_blank" >https://ieeexplore.ieee.org/document/7868926</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Popis výsledku v původním jazyce

QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

Název v anglickém jazyce

Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

Popis výsledku anglicky

QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/GAP102%2F12%2F2034" target="_blank" >GAP102/12/2034: Analýza vztahu mezi elektrickými ději a průtokem krve u srdečních komor</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology Conference

ISBN

978-1-5090-0895-7

ISSN

—

e-ISSN

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Počet stran výsledku

4

Strana od-do

1049-1052

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Vancouver

Datum konání akce

11. 9. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000405710400263