Responsive therapy with multi-stage detection of seizures in human epilepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F20%3APU138067" target="_blank" >RIV/00216305:26220/20:PU138067 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Responsive therapy with multi-stage detection of seizures in human epilepsy

Popis výsledku v původním jazyce

Rationale: Electrical brain stimulation (EBS) has been used successfully for treatment of drug resistant temporal lobe epilepsy. In particular, responsive neural stimulation (RNS) is an approach that delivers a brief electrical stimulation burst when epileptiform activity or seizure is detected. The RNS therapy is designed to be delivered to the brain region generating seizures. In the future it might be beneficial to track whether the initial stimulation therapy terminated the seizure, and in cases where stimulation has not stopped the seizure the therapy can be switched to a different network target. In that case, cascade detectors need to be enabled within the implanted neural stimulator (INS). We modelled, implemented, and investigated a multi-stage therapy control approach embedded in an INS to stimulate multiple brain targets with different stimulation settings. Methods: We created a database of intracranially recorded hippocampal seizures and interictal periods in patients undergoing surgical

Název v anglickém jazyce

Responsive therapy with multi-stage detection of seizures in human epilepsy

Popis výsledku anglicky

Rationale: Electrical brain stimulation (EBS) has been used successfully for treatment of drug resistant temporal lobe epilepsy. In particular, responsive neural stimulation (RNS) is an approach that delivers a brief electrical stimulation burst when epileptiform activity or seizure is detected. The RNS therapy is designed to be delivered to the brain region generating seizures. In the future it might be beneficial to track whether the initial stimulation therapy terminated the seizure, and in cases where stimulation has not stopped the seizure the therapy can be switched to a different network target. In that case, cascade detectors need to be enabled within the implanted neural stimulator (INS). We modelled, implemented, and investigated a multi-stage therapy control approach embedded in an INS to stimulate multiple brain targets with different stimulation settings. Methods: We created a database of intracranially recorded hippocampal seizures and interictal periods in patients undergoing surgical

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20601 - Medical engineering

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů