Shannon entropy: A novel tool for assessing pentagon drawing in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142428" target="_blank" >RIV/00216305:26220/21:PU142428 - isvavai.cz</a>

Výsledek na webu

<a href="https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.28794" target="_blank" >https://movementdisorders.onlinelibrary.wiley.com/doi/epdf/10.1002/mds.28794</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Shannon entropy: A novel tool for assessing pentagon drawing in Parkinson's disease

Popis výsledku v původním jazyce

Objective: We used a digitizing tablet during PCT as a potential tool for assessing early cognitive deficits in PD yet without major cognitive impairment. We also aimed to uncover neural correlates of identified parameter(s) using whole brain MRI. Background: Impaired copy of intersecting pentagons from MMSE (Pentagon Copy Test, PCT) has been shown to predict dementia in PD. Methods: We enrolled 27 PD patients without major cognitive impairment (median age 67.0, median disease duration 4.0.) and 25 age-matched healthy controls (HC) (median age 67.1). During parametrisation of drawing, we focused on the commonly used features and compared both groups using the Mann-Whitney U test. We further focused on parameters with significant correlation with cognitive domains’ z-scores. Selected parameters were used as covariates in the whole brain voxel-wise analysis using 3T MRI and voxel-based morphometry. Results: PD patients differed from HC only in attention domain (p<0.0001). Regarding the drawing parame

Název v anglickém jazyce

Shannon entropy: A novel tool for assessing pentagon drawing in Parkinson's disease

Popis výsledku anglicky

Objective: We used a digitizing tablet during PCT as a potential tool for assessing early cognitive deficits in PD yet without major cognitive impairment. We also aimed to uncover neural correlates of identified parameter(s) using whole brain MRI. Background: Impaired copy of intersecting pentagons from MMSE (Pentagon Copy Test, PCT) has been shown to predict dementia in PD. Methods: We enrolled 27 PD patients without major cognitive impairment (median age 67.0, median disease duration 4.0.) and 25 age-matched healthy controls (HC) (median age 67.1). During parametrisation of drawing, we focused on the commonly used features and compared both groups using the Mann-Whitney U test. We further focused on parameters with significant correlation with cognitive domains’ z-scores. Selected parameters were used as covariates in the whole brain voxel-wise analysis using 3T MRI and voxel-based morphometry. Results: PD patients differed from HC only in attention domain (p<0.0001). Regarding the drawing parame

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NU20-04-00294" target="_blank" >NU20-04-00294: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů