Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142430" target="_blank" >RIV/00216305:26220/21:PU142430 - isvavai.cz</a>
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease
Popis výsledku v původním jazyce
Background and aims: Hypokinetic dysarthria is a common symptom of Parkinson’s disease (PD) that does not respond well to PD treatments. We examined the longterm effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Methods: A randomized parallel-group sham stimulationcontrolled design was used. Patients were assigned to ten sessions of real (1 Hz) or sham stimulation over the right superior temporal gyrus (STG). Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Prosody, articulation and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score). Activations of the speech network regions, structural and functional connectivity were analyzed. Results: Altogether 33 PD patients completed the study. Linear mixed model showed significant time-by-group interactions for the Phonetics score (p=0.040). Real as compared to sham stimulation led to increased activations of the left
Název v anglickém jazyce
Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease
Popis výsledku anglicky
Background and aims: Hypokinetic dysarthria is a common symptom of Parkinson’s disease (PD) that does not respond well to PD treatments. We examined the longterm effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Methods: A randomized parallel-group sham stimulationcontrolled design was used. Patients were assigned to ten sessions of real (1 Hz) or sham stimulation over the right superior temporal gyrus (STG). Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Prosody, articulation and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score). Activations of the speech network regions, structural and functional connectivity were analyzed. Results: Altogether 33 PD patients completed the study. Linear mixed model showed significant time-by-group interactions for the Phonetics score (p=0.040). Real as compared to sham stimulation led to increased activations of the left
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30103 - Neurosciences (including psychophysiology)
Návaznosti výsledku
Projekt
<a href="/cs/project/NV16-30805A" target="_blank" >NV16-30805A: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů