Heart rate and age modulate retinal pulsatile patterns

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU144892" target="_blank" >RIV/00216305:26220/22:PU144892 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s42003-022-03441-6" target="_blank" >https://www.nature.com/articles/s42003-022-03441-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s42003-022-03441-6" target="_blank" >10.1038/s42003-022-03441-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Heart rate and age modulate retinal pulsatile patterns

Popis výsledku v původním jazyce

Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Název v anglickém jazyce

Heart rate and age modulate retinal pulsatile patterns

Popis výsledku anglicky

Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

<a href="/cs/project/GA21-18578S" target="_blank" >GA21-18578S: Funkční zobrazování sítnice s dvěma vlnovými délkami a současnou akvizicí biosignálů pro hodnocení očního krevního oběhu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Communications Biology

ISSN

2399-3642

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000811214900001

EID výsledku v databázi Scopus

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