Systems biology approach for analysis of mobile genetic elements in chicken gut microbiome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F22%3APU146245" target="_blank" >RIV/00216305:26220/22:PU146245 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.ieeecomputersociety.org/10.1109/BIBM55620.2022.9995414" target="_blank" >https://doi.ieeecomputersociety.org/10.1109/BIBM55620.2022.9995414</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/BIBM55620.2022.9995414" target="_blank" >10.1109/BIBM55620.2022.9995414</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Systems biology approach for analysis of mobile genetic elements in chicken gut microbiome

Popis výsledku v původním jazyce

Antibiotic use in farming for decades has led to the selection pressure on chicken commensal bacteria which adapted to those changes by the acquisition of antibiotic resistance genes via horizontal gene transfer. Extensive gene transfer between gut bacteria is mediated by mobile genetic elements such as plasmids, integrative conjugative elements and temperate phages. Therefore, chicken gut commensal bacteria are considered reservoirs of antibiotic resistance genes. Recently, we initiated a systemic cultivation of chicken gut anaerobes followed by subsequent whole genome sequencing and analysis. In this study, we implemented a novel in silico approach using systems biology methods to detect horizontal gene traits and mobile genetic elements associated with it in the genomes of chicken gut commensals. In total, we identified 1,427 genes envisaged to drive horizontal gene transfer between individual chicken gut microbiota members across different families. Except for genes known to be vertically transferred, we also revealed hypothetical genes which may represent important, yet unknown section of mobilome

Název v anglickém jazyce

Systems biology approach for analysis of mobile genetic elements in chicken gut microbiome

Popis výsledku anglicky

Antibiotic use in farming for decades has led to the selection pressure on chicken commensal bacteria which adapted to those changes by the acquisition of antibiotic resistance genes via horizontal gene transfer. Extensive gene transfer between gut bacteria is mediated by mobile genetic elements such as plasmids, integrative conjugative elements and temperate phages. Therefore, chicken gut commensal bacteria are considered reservoirs of antibiotic resistance genes. Recently, we initiated a systemic cultivation of chicken gut anaerobes followed by subsequent whole genome sequencing and analysis. In this study, we implemented a novel in silico approach using systems biology methods to detect horizontal gene traits and mobile genetic elements associated with it in the genomes of chicken gut commensals. In total, we identified 1,427 genes envisaged to drive horizontal gene transfer between individual chicken gut microbiota members across different families. Except for genes known to be vertically transferred, we also revealed hypothetical genes which may represent important, yet unknown section of mobilome

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

ISBN

978-1-4577-1799-4

ISSN

—

e-ISSN

—

Počet stran výsledku

6

Strana od-do

2865-2870

Název nakladatele

IEEE Computer Society

Místo vydání

neuveden

Místo konání akce

conference

Datum konání akce

6. 12. 2022

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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