Mathematical modeling of the effect of stent construction during endoluminal IRE for recanalization of an occluded metal stent

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F26%3A0191287" target="_blank" >RIV/00216305:26220/26:0191287 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00141725 RIV/65269705:_____/25:00082267

Výsledek na webu

<a href="https://www.tandfonline.com/doi/metrics/10.1080/02656736.2025.2520362" target="_blank" >https://www.tandfonline.com/doi/metrics/10.1080/02656736.2025.2520362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/02656736.2025.2520362" target="_blank" >10.1080/02656736.2025.2520362</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mathematical modeling of the effect of stent construction during endoluminal IRE for recanalization of an occluded metal stent

Popis výsledku v původním jazyce

Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metalstents. However, optimal IRE parameters for consistent effects across different stent designs remainunclear. The aim of this study was to simulate the process of stent recanalization in silico by employingfinite element analysis. Methods: A virtual model of an occluded biliary stent with an experimental 3-electrode IRE catheter was developed. Electric field distribution, temperature changes, and potential ablation volumes weresimulated across various parameters: IRE voltage (300 − 1300 V), stent wire width (0.1 − 0.5 mm) and stentmesh size (0.7 − 5.58 mm). Simulations incorporated five representative stent types commonly used inclinical practice. 685 unique simulations were conducted, analyzing 1162 unique values. Results: Higher voltages generally led to larger ablation zones and increased temperatures. Thinnerstent wires and larger mesh sizes also increased the extent of ablation zone. While in-stent ablation waslargely independent of stent design, out-of-stent ablation was significantly impacted by mesh size andtissue thickness between the stent and irreversible electroporation electrodes. Voltages above 1000 Vproduced significant thermal effects, with substantial volumes of tissue heated above 50 °C. Specificstent designs exhibited variations in maximum temperature (72.1 − 83.1 °C) and ablation volume(8.7 − 14.7 mm3). Conclusion: Tailored IRE protocols for different stent designs are required due to differences in in- andout-stent ablation volumes. High voltages (>1000 V) induce both thermal and nonthermal ablation mechanisms.

Název v anglickém jazyce

Mathematical modeling of the effect of stent construction during endoluminal IRE for recanalization of an occluded metal stent

Popis výsledku anglicky

Background: Intraluminal irreversible electroporation (IRE) can be used for recanalizing occluded metalstents. However, optimal IRE parameters for consistent effects across different stent designs remainunclear. The aim of this study was to simulate the process of stent recanalization in silico by employingfinite element analysis. Methods: A virtual model of an occluded biliary stent with an experimental 3-electrode IRE catheter was developed. Electric field distribution, temperature changes, and potential ablation volumes weresimulated across various parameters: IRE voltage (300 − 1300 V), stent wire width (0.1 − 0.5 mm) and stentmesh size (0.7 − 5.58 mm). Simulations incorporated five representative stent types commonly used inclinical practice. 685 unique simulations were conducted, analyzing 1162 unique values. Results: Higher voltages generally led to larger ablation zones and increased temperatures. Thinnerstent wires and larger mesh sizes also increased the extent of ablation zone. While in-stent ablation waslargely independent of stent design, out-of-stent ablation was significantly impacted by mesh size andtissue thickness between the stent and irreversible electroporation electrodes. Voltages above 1000 Vproduced significant thermal effects, with substantial volumes of tissue heated above 50 °C. Specificstent designs exhibited variations in maximum temperature (72.1 − 83.1 °C) and ablation volume(8.7 − 14.7 mm3). Conclusion: Tailored IRE protocols for different stent designs are required due to differences in in- andout-stent ablation volumes. High voltages (>1000 V) induce both thermal and nonthermal ablation mechanisms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/NU21-08-00561" target="_blank" >NU21-08-00561: Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of hyperthermia

ISSN

0265-6736

e-ISSN

1464-5157

Svazek periodika

42

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

1-14

Kód UT WoS článku

001522021000001

EID výsledku v databázi Scopus

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