Detection of Heavy Metal Contamination by Vibrational Spectroscopy: A Combined Theoretical and Experimental Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F26%3A0199132" target="_blank" >RIV/00216305:26220/26:0199132 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.13164/eeict.2025.195" target="_blank" >http://dx.doi.org/10.13164/eeict.2025.195</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.13164/eeict.2025.195" target="_blank" >10.13164/eeict.2025.195</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Detection of Heavy Metal Contamination by Vibrational Spectroscopy: A Combined Theoretical and Experimental Study

Popis výsledku v původním jazyce

Heavy metal infiltration into connective tissues remains a notable yet under-explored issue in biomaterials research. In this study, we employed Fourier Transform Infrared (FTIR) spectroscopy to investigate potential mercury-induced changes in dentin, with an emphasis on the attenuation of thiol (–SH) vibrational signatures as a key indicator. High-resolution spectra, combined with chemometric preprocessing, enabled the detection of subtle perturbations in sulfur-containing amino acid residues. A reduction in thiol band intensity tentatively suggests mercury interactions with sulfhydryl groups, implying possible disruptions in protein conformation and the dentin organic matrix. Small but consistent shifts in amide I and II regions further point to collateral effects on dentinal proteins. To minimize confounding factors, we utilized selective reference spectra and limited elemental mapping, supporting the specificity of these observed alterations to localized mercury presence. While the initial results indicate a correlation between mercury exposure and diminished thiol peaks, additional data and systematic validation are needed to confirm these findings and clarify their broader clinical significance.

Název v anglickém jazyce

Detection of Heavy Metal Contamination by Vibrational Spectroscopy: A Combined Theoretical and Experimental Study

Popis výsledku anglicky

Heavy metal infiltration into connective tissues remains a notable yet under-explored issue in biomaterials research. In this study, we employed Fourier Transform Infrared (FTIR) spectroscopy to investigate potential mercury-induced changes in dentin, with an emphasis on the attenuation of thiol (–SH) vibrational signatures as a key indicator. High-resolution spectra, combined with chemometric preprocessing, enabled the detection of subtle perturbations in sulfur-containing amino acid residues. A reduction in thiol band intensity tentatively suggests mercury interactions with sulfhydryl groups, implying possible disruptions in protein conformation and the dentin organic matrix. Small but consistent shifts in amide I and II regions further point to collateral effects on dentinal proteins. To minimize confounding factors, we utilized selective reference spectra and limited elemental mapping, supporting the specificity of these observed alterations to localized mercury presence. While the initial results indicate a correlation between mercury exposure and diminished thiol peaks, additional data and systematic validation are needed to confirm these findings and clarify their broader clinical significance.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20200 - Electrical engineering, Electronic engineering, Information engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings II of the Conference Student Eeict

ISBN

9788021463202

ISSN

—

e-ISSN

2788-1334

Počet stran výsledku

5

Strana od-do

195-199

Název nakladatele

Brno University of Technology

Místo vydání

—

Místo konání akce

Brno

Datum konání akce

29. 4. 2025

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

—