Influence of hypokinetic dysarthria severity level on the long-term outcome of repetitive transcranial magnetic stimulation therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F26%3A0201135" target="_blank" >RIV/00216305:26220/26:0201135 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1353802026000015" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1353802026000015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2026.108175" target="_blank" >10.1016/j.parkreldis.2026.108175</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of hypokinetic dysarthria severity level on the long-term outcome of repetitive transcranial magnetic stimulation therapy

Popis výsledku v původním jazyce

Introduction: Hypokinetic dysarthria (HD) is a common and disabling symptom of Parkinson's disease (PD) for which established pharmacological and surgical treatments bring only limited, often short-term improvement in speech. The aim of this study was to investigate whether the long-term acoustic effects of repetitive transcranial magnetic stimulation (rTMS) over the right superior temporal gyrus (STG) depend on the baseline severity of HD. Methods: 26 PD patients were randomized to active STG-targeted rTMS (n = 15) or sham stimulation (n =11) and followed across five recording sessions over 14 weeks, alongside one session of matched healthy controls. HD severity at baseline was quantified using 3F test subscores and used to stratify patients into milder (0) and more severe (1) subgroups. The STG 1 subgroup combined greater motor and speech impairment with shorter disease duration. Multiple acoustic features from sustained phonation and free monologue were extracted, normalized to controls, adjusted for sex, and analyzed using non-parametric statistics and descriptive visualisations. Results: Patients with more severe HD receiving active stimulation (STG 1) showed consistent, long-lasting improvements in phonation-related parameters, whereas milder HD (STG 0) and sham groups (SHAM 0, SHAM 1) exhibited only limited or transient changes. Conclusion: Given this observation, STG-targeted rTMS appears particularly beneficial for PD patients with more advanced HD, supporting auditory-motor network modulation as a therapeutic strategy and motivating larger, multi-centre trials to confirm these stratified effects and their clinical impact.

Název v anglickém jazyce

Influence of hypokinetic dysarthria severity level on the long-term outcome of repetitive transcranial magnetic stimulation therapy

Popis výsledku anglicky

Introduction: Hypokinetic dysarthria (HD) is a common and disabling symptom of Parkinson's disease (PD) for which established pharmacological and surgical treatments bring only limited, often short-term improvement in speech. The aim of this study was to investigate whether the long-term acoustic effects of repetitive transcranial magnetic stimulation (rTMS) over the right superior temporal gyrus (STG) depend on the baseline severity of HD. Methods: 26 PD patients were randomized to active STG-targeted rTMS (n = 15) or sham stimulation (n =11) and followed across five recording sessions over 14 weeks, alongside one session of matched healthy controls. HD severity at baseline was quantified using 3F test subscores and used to stratify patients into milder (0) and more severe (1) subgroups. The STG 1 subgroup combined greater motor and speech impairment with shorter disease duration. Multiple acoustic features from sustained phonation and free monologue were extracted, normalized to controls, adjusted for sex, and analyzed using non-parametric statistics and descriptive visualisations. Results: Patients with more severe HD receiving active stimulation (STG 1) showed consistent, long-lasting improvements in phonation-related parameters, whereas milder HD (STG 0) and sham groups (SHAM 0, SHAM 1) exhibited only limited or transient changes. Conclusion: Given this observation, STG-targeted rTMS appears particularly beneficial for PD patients with more advanced HD, supporting auditory-motor network modulation as a therapeutic strategy and motivating larger, multi-centre trials to confirm these stratified effects and their clinical impact.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LX22NPO5107" target="_blank" >LX22NPO5107: Národní ústav pro neurologický výzkum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parkinsonism & related disorders

ISSN

1353-8020

e-ISSN

1873-5126

Svazek periodika

144

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

—

Kód UT WoS článku

001673597200001

EID výsledku v databázi Scopus

2-s2.0-105027810220