FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F20%3APU138651" target="_blank" >RIV/00216305:26230/20:PU138651 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa337/6042664" target="_blank" >https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa337/6042664</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/bib/bbaa337" target="_blank" >10.1093/bib/bbaa337</a>

Jazyk výsledku

angličtina

Název v původním jazyce

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Popis výsledku v původním jazyce

There is a great interest in increasing proteins stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users side. FireProtASR aims to overcome this obstacle by constructing a fully automated workf low, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProtASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/.

Název v anglickém jazyce

FireProtASR: Web Server for Fully Automated Ancestral Sequence Reconstruction

Popis výsledku anglicky

There is a great interest in increasing proteins stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users side. FireProtASR aims to overcome this obstacle by constructing a fully automated workf low, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input. FireProtASR is complemented with an interactive, easy-to-use web interface and is freely available at https://loschmidt.chemi.muni.cz/fireprotasr/.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BRIEFINGS IN BIOINFORMATICS

ISSN

1467-5463

e-ISSN

1477-4054

Svazek periodika

0000

Číslo periodika v rámci svazku

0000

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000709466800097

EID výsledku v databázi Scopus

2-s2.0-85100417173