Determination of naturally-occuring alkaloids in feed by UPLC-MS/MS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F13%3APU105794" target="_blank" >RIV/00216305:26310/13:PU105794 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of naturally-occuring alkaloids in feed by UPLC-MS/MS

Popis výsledku v původním jazyce

Alkaloids, which are known as secondary metabolites, are produced by a large variety of organisms, including plants, fungi, bacteria and animals. Alkaloids are not crucial for the survival of the mentioned organisms, but for their protection. They are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. As other alkaloids PAs can cause severe human and animal health problems. Intoxications caused by PAs are described by hepatotoxicity with tendency to hemorrhagic necrosis and veno-occlusion in liver, pneumotoxicity, carcinogenity, mutagenity, and genotoxicity [1]. Thus, there is a need for methods that allow to determinate these dangerous plant toxins. In this study, fast, reliable and sensitive approach is proposed allowing simultaneous screening, identification and quantification of PAs in feed samples. Selected PAs representatives, namely monocrotaline, senkirkine, senecion

Název v anglickém jazyce

Determination of naturally-occuring alkaloids in feed by UPLC-MS/MS

Popis výsledku anglicky

Alkaloids, which are known as secondary metabolites, are produced by a large variety of organisms, including plants, fungi, bacteria and animals. Alkaloids are not crucial for the survival of the mentioned organisms, but for their protection. They are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. As other alkaloids PAs can cause severe human and animal health problems. Intoxications caused by PAs are described by hepatotoxicity with tendency to hemorrhagic necrosis and veno-occlusion in liver, pneumotoxicity, carcinogenity, mutagenity, and genotoxicity [1]. Thus, there is a need for methods that allow to determinate these dangerous plant toxins. In this study, fast, reliable and sensitive approach is proposed allowing simultaneous screening, identification and quantification of PAs in feed samples. Selected PAs representatives, namely monocrotaline, senkirkine, senecion

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů