In vitro bioactivity of silicon nitride-hydroxyapatite composites

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU136202" target="_blank" >RIV/00216305:26310/15:PU136202 - isvavai.cz</a>

Výsledek na webu

<a href="http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com.ezproxy.lib.vutbr.cz/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=E6JXvEJHJpsw8EibggE&page=1&doc=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ceramint.2015.03.011" target="_blank" >10.1016/j.ceramint.2015.03.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Popis výsledku v původním jazyce

Silicon nitride-based ceramics are characterised especially by high chemical resistance, superior combination of fracture toughness, hardness and bioinertness. However, the biological applications often require additional properties, e.g. bioactivity enabling stronger bonding to the host tissue. Hydroxyapatite coating prepared by sol gel route, which provides pure, stable and nano-crystalline product is one of the ways to achieve bioactivity of bioinert ceramics. Therefore silicon nitride hydroxyapatite composites were prepared by infiltration of hydroxyapatite precursor sol into the silicon nitride based porous ceramics. The conditions of sol preparation were optimised to be appropriate for pure HA synthesis: ageing at elevated temperature (85 degrees C) and calcinations at 500 degrees C for 1 h. Cytotoxicity and in vitro bioactivity of Si3N4-HA composites were tested in order to verify the effect of hydroxyapatite addition on the biological properties of composite. After immersion of porous composite into simulated body fluid (SBF) for 21 days, calcium phosphate layer was formed on the surface of silicon nitride hydroxyapatite composites, indicating their bioactivity. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Název v anglickém jazyce

In vitro bioactivity of silicon nitride-hydroxyapatite composites

Popis výsledku anglicky

Silicon nitride-based ceramics are characterised especially by high chemical resistance, superior combination of fracture toughness, hardness and bioinertness. However, the biological applications often require additional properties, e.g. bioactivity enabling stronger bonding to the host tissue. Hydroxyapatite coating prepared by sol gel route, which provides pure, stable and nano-crystalline product is one of the ways to achieve bioactivity of bioinert ceramics. Therefore silicon nitride hydroxyapatite composites were prepared by infiltration of hydroxyapatite precursor sol into the silicon nitride based porous ceramics. The conditions of sol preparation were optimised to be appropriate for pure HA synthesis: ageing at elevated temperature (85 degrees C) and calcinations at 500 degrees C for 1 h. Cytotoxicity and in vitro bioactivity of Si3N4-HA composites were tested in order to verify the effect of hydroxyapatite addition on the biological properties of composite. After immersion of porous composite into simulated body fluid (SBF) for 21 days, calcium phosphate layer was formed on the surface of silicon nitride hydroxyapatite composites, indicating their bioactivity. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

20504 - Ceramics

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CERAMICS INTERNATIONAL

ISSN

0272-8842

e-ISSN

1873-3956

Svazek periodika

41

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

8100-8108

Kód UT WoS článku

000354140300119

EID výsledku v databázi Scopus

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