The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU116586" target="_blank" >RIV/00216305:26310/16:PU116586 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.expresspolymlett.com/" target="_blank" >http://www.expresspolymlett.com/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3144/expresspolymlett.2016.34" target="_blank" >10.3144/expresspolymlett.2016.34</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties
Popis výsledku v původním jazyce
This paper deals with the influence of an incubation medium pH on the hydrolytic degradation of a novel thermosensitive biodegradable triblock copolymer based on hydrophilic poly(ethylene glycol) and hydrophobic copolymer poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA), consequently modified at alpha,omega-ends with itaconic acid (ITA) resulting in alpha,omega-itaconyl(PLGA-PEG-PLGA). Itaconic acid, gained from renewable resources, delivers a reactive double bond and carboxylic functional group to the end of PLGA-PEG-PLGA copolymer: this is important for a reaction with biologically active substances. The suitability of the sample degradation was assessed depending on whether the copolymer formed a gel at 37 °C. Two reversible physical sol-gel-sol transitions from a sol (liquid phase) to a gel (solid phase) and back to a sol (suspension) were verified using the tube inverting method. The hydrolytical degradation was evaluated at a physiological temperature (37 °C) in the presence of phosphate solutions, at a pH either 4.2 or 7.4 by monitoring the decrease of the number average molecular weight of copolymers by GPC. Moreover, the degradation kinetics was confirmed by the HPLC/DAD method, where the increasing amount of final degradation products (lactic and glycolic acids) was detected. The study demonstrated that the carboxylic groups modified copolymer is more susceptible to hydrolytical degradation than the unmodified copolymer within first days of degradation at 7.4.
Název v anglickém jazyce
The Effect of PLGA-PEG-PLGA Modification on the Sol-gel Transition and Degradation Properties
Popis výsledku anglicky
This paper deals with the influence of an incubation medium pH on the hydrolytic degradation of a novel thermosensitive biodegradable triblock copolymer based on hydrophilic poly(ethylene glycol) and hydrophobic copolymer poly(lactic acid-co-glycolic acid) (PLGA-PEG-PLGA), consequently modified at alpha,omega-ends with itaconic acid (ITA) resulting in alpha,omega-itaconyl(PLGA-PEG-PLGA). Itaconic acid, gained from renewable resources, delivers a reactive double bond and carboxylic functional group to the end of PLGA-PEG-PLGA copolymer: this is important for a reaction with biologically active substances. The suitability of the sample degradation was assessed depending on whether the copolymer formed a gel at 37 °C. Two reversible physical sol-gel-sol transitions from a sol (liquid phase) to a gel (solid phase) and back to a sol (suspension) were verified using the tube inverting method. The hydrolytical degradation was evaluated at a physiological temperature (37 °C) in the presence of phosphate solutions, at a pH either 4.2 or 7.4 by monitoring the decrease of the number average molecular weight of copolymers by GPC. Moreover, the degradation kinetics was confirmed by the HPLC/DAD method, where the increasing amount of final degradation products (lactic and glycolic acids) was detected. The study demonstrated that the carboxylic groups modified copolymer is more susceptible to hydrolytical degradation than the unmodified copolymer within first days of degradation at 7.4.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10406 - Analytical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
EXPRESS POLYM LETT
ISSN
1788-618X
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
HU - Maďarsko
Počet stran výsledku
12
Strana od-do
361-372
Kód UT WoS článku
000371669000002
EID výsledku v databázi Scopus
2-s2.0-84959370881