Turbidimetry and Fluorescence Study of Effect of Hyaluronan Addition to Cationic Micellar Solution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU120312" target="_blank" >RIV/00216305:26310/16:PU120312 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ipfdd.de/fileadmin/user_upload/oea/00_Tagungsband_ESOPS20_2016-09-15.pdf" target="_blank" >http://www.ipfdd.de/fileadmin/user_upload/oea/00_Tagungsband_ESOPS20_2016-09-15.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Turbidimetry and Fluorescence Study of Effect of Hyaluronan Addition to Cationic Micellar Solution

Popis výsledku v původním jazyce

Hyaluronan as negatively charged polyelectrolyte can interact with positively charged surfactant micelles via electrostatic interactions to form core-shell like aggregates. These self-assembly systems can solubilize hydrophobic active substances and therefore, they are potential carriers in drug delivery applications. This study deals with electrostatic association of cationic micelles of CTAB or Septonex with hyaluronan. The cationic micelle/hyaluronan complexes were studied using turbidimetry and fluorescence spectroscopy method. Turbidimetric titration was chosen as an indicator of the loss of transmitted light intensity due to the scattering effect of particles associated from hyaluronan and surfactant in it. Fluorescent probe pyrene was selected for spectroscopy experiments because of its unique sensitivity to polarity of the medium, so this fluorescence method was used as an indicator of presence of hydrophobic domains in the system. Effect of components concentration and molecular weight of hya

Název v anglickém jazyce

Turbidimetry and Fluorescence Study of Effect of Hyaluronan Addition to Cationic Micellar Solution

Popis výsledku anglicky

Hyaluronan as negatively charged polyelectrolyte can interact with positively charged surfactant micelles via electrostatic interactions to form core-shell like aggregates. These self-assembly systems can solubilize hydrophobic active substances and therefore, they are potential carriers in drug delivery applications. This study deals with electrostatic association of cationic micelles of CTAB or Septonex with hyaluronan. The cationic micelle/hyaluronan complexes were studied using turbidimetry and fluorescence spectroscopy method. Turbidimetric titration was chosen as an indicator of the loss of transmitted light intensity due to the scattering effect of particles associated from hyaluronan and surfactant in it. Fluorescent probe pyrene was selected for spectroscopy experiments because of its unique sensitivity to polarity of the medium, so this fluorescence method was used as an indicator of presence of hydrophobic domains in the system. Effect of components concentration and molecular weight of hya

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů