Hydrogels based on cationic polyelectrolytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F17%3APU124406" target="_blank" >RIV/00216305:26310/17:PU124406 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hydrogels based on cationic polyelectrolytes

Popis výsledku v původním jazyce

The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.

Název v anglickém jazyce

Hydrogels based on cationic polyelectrolytes

Popis výsledku anglicky

The main aim of this work is laboratory preparation and characterization of hydrogels based on cationic polyelectrolytes. Cationic polyelectrolytes can interact with oppositely charged surfactants via electrostatic forces. Interactions between cationic polyelectrolytes and anionic surfactants can generate physical gels (under proper conditions such as temperature, pH, ionic strenght) and surfactants are able to form micellar structures suitable for solubilizing hydrophobic compounds in aqueous environment of the gel. Resulting materials are hydrogels which contain hydrophobic nanodomains so it is possible to use like porters in drug delivery in medicine, e.g. hydrophobic drugs for topical applications (wound healing and so on). The presence of hydrophobic nanodomains was tested by solubilization tests with the help of hydrophobic dyes (e.g. Oil red O, prodan). Mechanical properties of prepared materials were tested rheologically (in dependence of their composition). This work is focused on the preparation of gels from positively charged polysaccharides dextran hydrochloride and negatively charged surfactant sodium dodecyl sulphate.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Sborník příspěvků

ISBN

978-80-214-5489-7

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

194-197

Název nakladatele

Vysoké učení technické v Brně, Fakulta chemická

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

23. 3. 2017

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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