Advanced Microrheological Techniques In The Research Of Hydrogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F17%3APU124781" target="_blank" >RIV/00216305:26310/17:PU124781 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Advanced Microrheological Techniques In The Research Of Hydrogels

Popis výsledku v původním jazyce

This work is focused on the use of advanced fluorescence correlation spectroscopy technique (FCS) in microrheological characterization of hydrogels. Hydrogels were prepared from negatively charged polymer (sodium hyaluronate) and oppositely charged surfactant (cetyltrimethylammonium bromide) in physiological environment. Low, medium and high molecular weight sodium hyaluronate was used. Our hydrogels contain more than 90 % of water and they are able to solubilize hydrophobic and hydrophilic species. These hydrogels contain hydrophobic nanodomains (nanocontainers) and can be promising materials for the use in many applications, e.g. in topical applications or local drug delivery systems. Main aim of this work is to study microrhelological behavior of these systems and usability of FCS technique in these systems. For microrheological FCS analysis were used fluorescently labelled particles. Optimum particle size was selected based on analysis of Newtonian glycerol solutions. The results of FCS hydrogel m

Název v anglickém jazyce

Advanced Microrheological Techniques In The Research Of Hydrogels

Popis výsledku anglicky

This work is focused on the use of advanced fluorescence correlation spectroscopy technique (FCS) in microrheological characterization of hydrogels. Hydrogels were prepared from negatively charged polymer (sodium hyaluronate) and oppositely charged surfactant (cetyltrimethylammonium bromide) in physiological environment. Low, medium and high molecular weight sodium hyaluronate was used. Our hydrogels contain more than 90 % of water and they are able to solubilize hydrophobic and hydrophilic species. These hydrogels contain hydrophobic nanodomains (nanocontainers) and can be promising materials for the use in many applications, e.g. in topical applications or local drug delivery systems. Main aim of this work is to study microrhelological behavior of these systems and usability of FCS technique in these systems. For microrheological FCS analysis were used fluorescently labelled particles. Optimum particle size was selected based on analysis of Newtonian glycerol solutions. The results of FCS hydrogel m

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů