Adaptation of Cupriavidus necator H16 to levulinic acid for enhancement of 3-hydroxyvalerate content in copolymer P(3HB-co-3HV)
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU129873" target="_blank" >RIV/00216305:26310/18:PU129873 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Adaptation of Cupriavidus necator H16 to levulinic acid for enhancement of 3-hydroxyvalerate content in copolymer P(3HB-co-3HV)
Popis výsledku v původním jazyce
Within this work we used methods of evolutionary engineering to gain strains adapted to levulinic acid able to growth at the presence of levulinic acid and to convert it to 3HV and incorporate into copolymer P(3HB-co-3HV) more than wild-type strain. On the basis of specific enzyme activities of selected enzymes through metabolism of evolved strains we tried to suggest possible metabolic adaptation strategies and we also used methods of statistical analysis such as PCA and AHC for searching of common and different strategies between evolved strains.
Název v anglickém jazyce
Adaptation of Cupriavidus necator H16 to levulinic acid for enhancement of 3-hydroxyvalerate content in copolymer P(3HB-co-3HV)
Popis výsledku anglicky
Within this work we used methods of evolutionary engineering to gain strains adapted to levulinic acid able to growth at the presence of levulinic acid and to convert it to 3HV and incorporate into copolymer P(3HB-co-3HV) more than wild-type strain. On the basis of specific enzyme activities of selected enzymes through metabolism of evolved strains we tried to suggest possible metabolic adaptation strategies and we also used methods of statistical analysis such as PCA and AHC for searching of common and different strategies between evolved strains.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů