Polyhadroxyalkanoates –microbial polyesters with a complex protective effect against diverse stress factors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU129881" target="_blank" >RIV/00216305:26310/18:PU129881 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polyhadroxyalkanoates –microbial polyesters with a complex protective effect against diverse stress factors

Popis výsledku v původním jazyce

Polyhydroxyalkanoates (PHAs) are hydrophobic polyesters produced and accumulated by numerous microorganisms in a form of intracellular granules filled with the polymer and covered by a layer of proteins. The polymer content of bacteria can reach up to 90 % of the weight of cellular dry matter. In our recent work, we have confirmed experimentally that PHAs granules do not serve only as a source of carbon or energy but also as a cell component with a complex protective performance. PHAs accumulating bacteria cells are synthesizing and degrading the polymers simultaneously. We have confirmed that the monomer of PHAs, which is found in the polymer-accumulating bacterial in a substantial amount, serves as a chemical chaperone and a cryo- protective solute. Furthermore, we have revealed that the protective function of the polymer against various stressors such as non-optimal pH, high and low temperature, osmotic up- and down-shock, UV exposure etc. is conditioned by the native amorphous state of PHAs. This

Název v anglickém jazyce

Polyhadroxyalkanoates –microbial polyesters with a complex protective effect against diverse stress factors

Popis výsledku anglicky

Polyhydroxyalkanoates (PHAs) are hydrophobic polyesters produced and accumulated by numerous microorganisms in a form of intracellular granules filled with the polymer and covered by a layer of proteins. The polymer content of bacteria can reach up to 90 % of the weight of cellular dry matter. In our recent work, we have confirmed experimentally that PHAs granules do not serve only as a source of carbon or energy but also as a cell component with a complex protective performance. PHAs accumulating bacteria cells are synthesizing and degrading the polymers simultaneously. We have confirmed that the monomer of PHAs, which is found in the polymer-accumulating bacterial in a substantial amount, serves as a chemical chaperone and a cryo- protective solute. Furthermore, we have revealed that the protective function of the polymer against various stressors such as non-optimal pH, high and low temperature, osmotic up- and down-shock, UV exposure etc. is conditioned by the native amorphous state of PHAs. This

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů