Characterization of albumin and hyaluronan‑albumin mixed hydrogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU141530" target="_blank" >RIV/00216305:26310/21:PU141530 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11696-021-01853-y" target="_blank" >https://link.springer.com/article/10.1007/s11696-021-01853-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11696-021-01853-y" target="_blank" >10.1007/s11696-021-01853-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of albumin and hyaluronan‑albumin mixed hydrogels

Popis výsledku v původním jazyce

Various hydrogels prepared from natural polymers have found great use in different industries, including, but not limited to, biomedicine. Recent trends in the material development focus on the preparation of hydrogels based on two or more biopolymers to combine their properties, which leads to better performance of a resulting material. In the present work, albumin and mixed hyaluronan-albumin hydrogels were characterized using various methods. The rheological properties of the samples varied based on the sample composition. The addition of hyaluronan to the albumin samples lowered the crosslink density of the hydrogels resulting in the lower complex modulus values and the higher equilibrium swelling ratio. Increasing the ionic strength of the sample shifted the albumin denaturation temperature of the water solutions to higher temperatures and suppressed the effect of hyaluronan on the denaturation. Scanning electron microscopy images showed that the microstructure of albumin samples significantly differs from the structure of mixed hyaluronan-albumin samples. The release profiles of a reference dye (methylene blue) showed, that the diffusion of the dye was rather slow. The released amounts of a dye from hydrogel into the buffer (physiological conditions model) varied from 6.35 ± 0.35% up to 9.78 ± 1.42% (after 96 h).

Název v anglickém jazyce

Characterization of albumin and hyaluronan‑albumin mixed hydrogels

Popis výsledku anglicky

Various hydrogels prepared from natural polymers have found great use in different industries, including, but not limited to, biomedicine. Recent trends in the material development focus on the preparation of hydrogels based on two or more biopolymers to combine their properties, which leads to better performance of a resulting material. In the present work, albumin and mixed hyaluronan-albumin hydrogels were characterized using various methods. The rheological properties of the samples varied based on the sample composition. The addition of hyaluronan to the albumin samples lowered the crosslink density of the hydrogels resulting in the lower complex modulus values and the higher equilibrium swelling ratio. Increasing the ionic strength of the sample shifted the albumin denaturation temperature of the water solutions to higher temperatures and suppressed the effect of hyaluronan on the denaturation. Scanning electron microscopy images showed that the microstructure of albumin samples significantly differs from the structure of mixed hyaluronan-albumin samples. The release profiles of a reference dye (methylene blue) showed, that the diffusion of the dye was rather slow. The released amounts of a dye from hydrogel into the buffer (physiological conditions model) varied from 6.35 ± 0.35% up to 9.78 ± 1.42% (after 96 h).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

1336-9075

Svazek periodika

75

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000692988600003

EID výsledku v databázi Scopus

2-s2.0-85114313363