How the presence of lecithin nanodomains affects the transport properties of hydrogels - potential controlled release drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU142373" target="_blank" >RIV/00216305:26310/21:PU142373 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

How the presence of lecithin nanodomains affects the transport properties of hydrogels - potential controlled release drug delivery

Popis výsledku v původním jazyce

Hydrogels are presently under investigation due to their similarities with the native extracellular matrix (ECM). These unique materials could serve as a suitable platform for studying transport of soluble molecules. As is known, transport properties of the materials are given by their internal structure and could be greatly affected by its rearrangement. Thus the aim of this study is to investigate the influence of the lecithin nanodomains as a structure modifier on the transport properties of hydrogel systems. For this purpose physically and chemically crosslinked hydrogels, containing lecithin and cationic organic dye rhodamin 6G as a diffusion probe, were synthetized. The releasing of model active compound (organic dye) as well as structure modifier (lecithin) were determined via UV-VIS spectroscopy over the time. Based on the obtained data, effective diffusion coefficients and concentrations of the released dye were determined. Finally the limitations and advantages of the chosen hydrogels as a p

Název v anglickém jazyce

How the presence of lecithin nanodomains affects the transport properties of hydrogels - potential controlled release drug delivery

Popis výsledku anglicky

Hydrogels are presently under investigation due to their similarities with the native extracellular matrix (ECM). These unique materials could serve as a suitable platform for studying transport of soluble molecules. As is known, transport properties of the materials are given by their internal structure and could be greatly affected by its rearrangement. Thus the aim of this study is to investigate the influence of the lecithin nanodomains as a structure modifier on the transport properties of hydrogel systems. For this purpose physically and chemically crosslinked hydrogels, containing lecithin and cationic organic dye rhodamin 6G as a diffusion probe, were synthetized. The releasing of model active compound (organic dye) as well as structure modifier (lecithin) were determined via UV-VIS spectroscopy over the time. Based on the obtained data, effective diffusion coefficients and concentrations of the released dye were determined. Finally the limitations and advantages of the chosen hydrogels as a p

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Kvalitní interní granty VUT</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů