The effect of aminooxy-linkers' structure on the mechanical properties of hyaluronan-oxime hydrogels
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F22%3APU147695" target="_blank" >RIV/00216305:26310/22:PU147695 - isvavai.cz</a>
Výsledek na webu
<a href="https://web-p-ebscohost-com.ezproxy.lib.vutbr.cz/ehost/pdfviewer/pdfviewer?vid=0&sid=8dd8c0ea-6e22-44c5-b745-c30352736dd8%40redis" target="_blank" >https://web-p-ebscohost-com.ezproxy.lib.vutbr.cz/ehost/pdfviewer/pdfviewer?vid=0&sid=8dd8c0ea-6e22-44c5-b745-c30352736dd8%40redis</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3144/expresspolymlett.2022.21" target="_blank" >10.3144/expresspolymlett.2022.21</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effect of aminooxy-linkers' structure on the mechanical properties of hyaluronan-oxime hydrogels
Popis výsledku v původním jazyce
The wide range of hydrogel applications is a result of the optimization of gelation. Herein, the various aminooxylinkers were synthesized to study the kinetics of gelation and mechanical properties of hydrogels prepared by crosslinking of aldehyde-modified N-acetylglucosamine (GlcNAc) of hyaluronan (Delta HA-CHO: 4,5-anhydro-6-(GlcNAc)-oxo hyaluronan or HA-CHO: 6-(GlcNAc)-oxo hyaluronan). Structural characteristics of the linkers (length, number of functional groups and rigidity) and the polymer (effect of the -C=C- double bond) were investigated in detail and showed decreasing mechanical stiffness with increasing hydrophobic character of linker and effect of its rigidity/flexibility on imine conversion. Besides known linear bis(aminooxy)alkanes with different lengths of the chain, new multifunctional aminooxy-linkers: 1,3,5tris(aminooxymethyl)benzene and multikis(6-aminooxy-6-deoxy)-beta-cyclodextrin were prepared and shortened the gelation time. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) analysis showed that despite the aminooxylinkers ' cytotoxicity at higher concentrations, the final oxime hydrogels are non-cytotoxic and therefore are suitable for medicinal applications.
Název v anglickém jazyce
The effect of aminooxy-linkers' structure on the mechanical properties of hyaluronan-oxime hydrogels
Popis výsledku anglicky
The wide range of hydrogel applications is a result of the optimization of gelation. Herein, the various aminooxylinkers were synthesized to study the kinetics of gelation and mechanical properties of hydrogels prepared by crosslinking of aldehyde-modified N-acetylglucosamine (GlcNAc) of hyaluronan (Delta HA-CHO: 4,5-anhydro-6-(GlcNAc)-oxo hyaluronan or HA-CHO: 6-(GlcNAc)-oxo hyaluronan). Structural characteristics of the linkers (length, number of functional groups and rigidity) and the polymer (effect of the -C=C- double bond) were investigated in detail and showed decreasing mechanical stiffness with increasing hydrophobic character of linker and effect of its rigidity/flexibility on imine conversion. Besides known linear bis(aminooxy)alkanes with different lengths of the chain, new multifunctional aminooxy-linkers: 1,3,5tris(aminooxymethyl)benzene and multikis(6-aminooxy-6-deoxy)-beta-cyclodextrin were prepared and shortened the gelation time. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) analysis showed that despite the aminooxylinkers ' cytotoxicity at higher concentrations, the final oxime hydrogels are non-cytotoxic and therefore are suitable for medicinal applications.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10400 - Chemical sciences
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
EXPRESS POLYM LETT
ISSN
1788-618X
e-ISSN
—
Svazek periodika
16
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
HU - Maďarsko
Počet stran výsledku
14
Strana od-do
265-278
Kód UT WoS článku
000752462200005
EID výsledku v databázi Scopus
2-s2.0-85125920148