Diffusion of sulphonamide antibiotics in agarose hydrogels enriched by humic acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F23%3APU148251" target="_blank" >RIV/00216305:26310/23:PU148251 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0927775723009093?utm_campaign=STMJ_AUTH_SERV_PUBLISHED&utm_medium=email&utm_acid=101843882&SIS_ID=&dgcid=STMJ_AUTH_SERV_PUBLISHED&CMX_ID=&utm_in=DM379129&utm_source=AC_" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927775723009093?utm_campaign=STMJ_AUTH_SERV_PUBLISHED&utm_medium=email&utm_acid=101843882&SIS_ID=&dgcid=STMJ_AUTH_SERV_PUBLISHED&CMX_ID=&utm_in=DM379129&utm_source=AC_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2023.131825" target="_blank" >10.1016/j.colsurfa.2023.131825</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diffusion of sulphonamide antibiotics in agarose hydrogels enriched by humic acids

Popis výsledku v původním jazyce

Many different pharmaceuticals can evince potentially dangerous behaviour in soil and aqueous environments. Their migration ability and toxicity can be significantly affected by interactions with organic matter. Sulfamethoxazole and sulphapyridine (used as representative commonly used sulphonamide antibiotics) are studied from the point of view of their transport in model hydrogels containing humic substances. Agarose hydrogel was used as a model medium for the transport experiments. Standard Elliot soil humic acid (4S102H) purchased from International Humic Substances Society was incorporated into the hydrogel as an active substance (and representant of organic matter) for interactions with antibiotics and potential suppression of their migration and toxicity in soil systems. Two different experimental arrangements were used: the diffusion from constant source, and the diffusion couple. Diffusion coefficients were determined for pure agarose hydrogels as well as for hydrogels containing humic acids and compared. It was found that the addition of humic acids into hydrogel resulted in the decrease in the effective diffusion coefficient of sulphapyridine and the increase in the effective diffusion coefficient of sulfamethoxazole. Humic acids can suppress the mobility of sulphapyridine and enhance the diffusion of sulfamethoxazole. Batch sorption experiments provided similar adsorption capacities of humic acids for both studied antibiotics. The ratio between adsorption and desorption rate constants were higher than 1 for sulphapyridine and lower than 1 for sulfamethoxazole. It indicated that adsorption predominated for sulphapyridine which resulted in observed lower diffusivity. Desorption experiments showed that a majority of sulphapyridine can be immobilized by interaction with humic acids whereas much more free movable sulfamethoxazole was determined in the comparison with immobilized one.

Název v anglickém jazyce

Diffusion of sulphonamide antibiotics in agarose hydrogels enriched by humic acids

Popis výsledku anglicky

Many different pharmaceuticals can evince potentially dangerous behaviour in soil and aqueous environments. Their migration ability and toxicity can be significantly affected by interactions with organic matter. Sulfamethoxazole and sulphapyridine (used as representative commonly used sulphonamide antibiotics) are studied from the point of view of their transport in model hydrogels containing humic substances. Agarose hydrogel was used as a model medium for the transport experiments. Standard Elliot soil humic acid (4S102H) purchased from International Humic Substances Society was incorporated into the hydrogel as an active substance (and representant of organic matter) for interactions with antibiotics and potential suppression of their migration and toxicity in soil systems. Two different experimental arrangements were used: the diffusion from constant source, and the diffusion couple. Diffusion coefficients were determined for pure agarose hydrogels as well as for hydrogels containing humic acids and compared. It was found that the addition of humic acids into hydrogel resulted in the decrease in the effective diffusion coefficient of sulphapyridine and the increase in the effective diffusion coefficient of sulfamethoxazole. Humic acids can suppress the mobility of sulphapyridine and enhance the diffusion of sulfamethoxazole. Batch sorption experiments provided similar adsorption capacities of humic acids for both studied antibiotics. The ratio between adsorption and desorption rate constants were higher than 1 for sulphapyridine and lower than 1 for sulfamethoxazole. It indicated that adsorption predominated for sulphapyridine which resulted in observed lower diffusivity. Desorption experiments showed that a majority of sulphapyridine can be immobilized by interaction with humic acids whereas much more free movable sulfamethoxazole was determined in the comparison with immobilized one.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

ISSN

0927-7757

e-ISSN

1873-4359

Svazek periodika

673

Číslo periodika v rámci svazku

131825

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

„“-„“

Kód UT WoS článku

001054731300001

EID výsledku v databázi Scopus

2-s2.0-85161348946