Thermogelling properties of injectable functionalized hydrogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F12%3APU102272" target="_blank" >RIV/00216305:26620/12:PU102272 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Thermogelling properties of injectable functionalized hydrogels

Popis výsledku v původním jazyce

Proposed work deals with preparation, characterization and rheological study of well-defined smart injectable hydrogels from biodegradable, biocompatible, controlled life-time copolymers based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly([(lactic acid)-co-(glycolic acid)] (PLA/PGA) copolymer. Thermosensitive PLGA-PEG-PLGA copolymer with PLGA/PEG weight ratio of 1.5; 2; 2.5; 3.0 and LA/GA molar ratio equal to 2.4; 3.0 and 3.4 were prepared and additionally functionalized by itaconic anhydride (ITA) bringing both reactive carbon double bonds and functional -COOH groups to polymer both ends. Aqueous solutions of both modified and unmodified copolymers are able to form free flowing sol at room temperature and clear gel at temperature around 37 deg.C. Therefore, sol-gel transitions, thermogelling and viscoelastic properties were investigated using both test tube inverting method (TTIM) and rheometer. Combined methods give comprehensive information about changing in color,

Název v anglickém jazyce

Thermogelling properties of injectable functionalized hydrogels

Popis výsledku anglicky

Proposed work deals with preparation, characterization and rheological study of well-defined smart injectable hydrogels from biodegradable, biocompatible, controlled life-time copolymers based on hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly([(lactic acid)-co-(glycolic acid)] (PLA/PGA) copolymer. Thermosensitive PLGA-PEG-PLGA copolymer with PLGA/PEG weight ratio of 1.5; 2; 2.5; 3.0 and LA/GA molar ratio equal to 2.4; 3.0 and 3.4 were prepared and additionally functionalized by itaconic anhydride (ITA) bringing both reactive carbon double bonds and functional -COOH groups to polymer both ends. Aqueous solutions of both modified and unmodified copolymers are able to form free flowing sol at room temperature and clear gel at temperature around 37 deg.C. Therefore, sol-gel transitions, thermogelling and viscoelastic properties were investigated using both test tube inverting method (TTIM) and rheometer. Combined methods give comprehensive information about changing in color,

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů