Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F15%3APU115177" target="_blank" >RIV/00216305:26620/15:PU115177 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ceitec.eu/creating-life-in-3d/poster-session/" target="_blank" >http://www.ceitec.eu/creating-life-in-3d/poster-session/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Popis výsledku v původním jazyce

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing ?-D-galactose, L-rhamnose, ?-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ? 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

Název v anglickém jazyce

Natural polysaccharide Gum Karaya as novel biomaterial in regenerative medicine

Popis výsledku anglicky

Natural polysaccharides are biodegradable, freely available, relatively cheap and nontoxic materials with great potential in medical applications. The polysaccharide hydrogels supports wound healing by providing moist environment and can be utilized as wound dressing for soft tissue regeneration (e.g. skin burns or ulcers). One suitable candidate is Gum Karaya (GK), anionic polysaccharide containing ?-D-galactose, L-rhamnose, ?-D-glucuronic acid and D-galacturonic acid. Natural GK is partially acetylated high molecular weight polymer (Mw ? 9 mil Da), water insoluble, having high swelling and retention capacity, high viscosity and inherent antimicrobial activity. [1, 2, 3] The objective of this study is to prepare a soluble sample of GK by alkali treatment followed by designing new procedure for GK hydrogel preparation which meets requirements for use as wound healing coverings. Prepared samples were characterized by SEM, FTIR, NMR, TGA, DSC and rheology.

Druh

O - Ostatní výsledky

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů