Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F16%3APU119723" target="_blank" >RIV/00216305:26620/16:PU119723 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

Popis výsledku v původním jazyce

Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.

Název v anglickém jazyce

Novel Chitin/chitosan-glucan Wound Dressing: Isolation, Characterization and Medical Applications

Popis výsledku anglicky

Chitin/chitosan-glucan complex (ChCsGC) was isolated from schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15 °C) 8 wt. % urea/6 wt. % NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical and surface morphology. Prepared materials were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C-NMR, SEM and XRD techniques. The biological activity of the nonwoven ChCsGC fabric was tested against Escherichia coli (E.coli) bacteria exhibiting excellent antibacterial activity. The cell viability of the extracted complex and nonwovens were evaluated utilizing mouse fibroblast cell line varying concentration and treatment time. ChCsGC didn’t show any cytotoxicity against mouse fibroblast cells. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability of when tested using rat models.

Druh

A - Audiovizuální tvorba

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

978-80-86238-82-1

Místo vydání

Neuveden

Název nakladatele resp. objednatele

Neuveden

Verze

Neuveden

Identifikační číslo nosiče

—