Combination of X-ray micro-Computed tomography and laser-ablation based analytical techniques for 3D high resolution elemental mapping

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F16%3APU121351" target="_blank" >RIV/00216305:26620/16:PU121351 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Combination of X-ray micro-Computed tomography and laser-ablation based analytical techniques for 3D high resolution elemental mapping

Popis výsledku v původním jazyce

Detection and chemical 3D mapping of nanoparticles (NPs) distribution in biospecimen is a challenging task that can be met by simultaneous utilization of imaging techniques. Here we focus on the synergy of X-Ray micro-Computed Tomography (μCT), Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) for investigation of various nanoparticles (Gd, Ti, Pb, etc.) distributed in organs. Special emphasis is given to the analysis of nanoparticles in a murine kidney in 3D. Firstly, we have demonstrated the 3D visualization capabilities in soft tissues by iodine staining with μCT. Next, subsequent LIBS and LA-ICP-MS analysis enabled to identify nanoparticles distribution in the sample. Thus, this combination provides a novel analytical approach how to quickly visualize and recognize different elements in soft tissues.

Název v anglickém jazyce

Combination of X-ray micro-Computed tomography and laser-ablation based analytical techniques for 3D high resolution elemental mapping

Popis výsledku anglicky

Detection and chemical 3D mapping of nanoparticles (NPs) distribution in biospecimen is a challenging task that can be met by simultaneous utilization of imaging techniques. Here we focus on the synergy of X-Ray micro-Computed Tomography (μCT), Laser-Induced Breakdown Spectroscopy (LIBS) and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) for investigation of various nanoparticles (Gd, Ti, Pb, etc.) distributed in organs. Special emphasis is given to the analysis of nanoparticles in a murine kidney in 3D. Firstly, we have demonstrated the 3D visualization capabilities in soft tissues by iodine staining with μCT. Next, subsequent LIBS and LA-ICP-MS analysis enabled to identify nanoparticles distribution in the sample. Thus, this combination provides a novel analytical approach how to quickly visualize and recognize different elements in soft tissues.

Druh

D - Stať ve sborníku

CEP obor

JA - Elektronika a optoelektronika, elektrotechnika

OECD FORD obor

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Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

13th International Interdisciplinary Meeting on Bioanalysis

ISBN

978-80-904959-4-4

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

253-255

Název nakladatele

Neuveden

Místo vydání

Neuveden

Místo konání akce

Brno

Datum konání akce

17. 10. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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