Evaluation of aerosol deposition in a realistic human airway model by PET/CT
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU130874" target="_blank" >RIV/00216305:26620/18:PU130874 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Evaluation of aerosol deposition in a realistic human airway model by PET/CT
Popis výsledku v původním jazyce
The investigation of the drug delivery into the lungs is essential for the effectiveness determination of their treatment. The numerical models are developed for the theoretical calculation of the particle deposition. The realistic human airway models were manufactured for the evaluation of the theoretical results. The overall drug accumulation is calculated but it is not possible to achieve the local deposition. The combined Positron Emission Tomography and X-ray Computed Tomography (PET/CT) imaging was applied for the local deposition analysis. The new algorithm for the precise identification of the individual section of the airway model in the CT data was created. PET/CT images were employed for the localization of deposited aerosol in the realistic model of the oral cavity and the following seven generation of the tracheobronchial tree. The realistic human airway model and the developed algorithm represent the new method for the precise local deposition of aerosol evaluation in human lungs.
Název v anglickém jazyce
Evaluation of aerosol deposition in a realistic human airway model by PET/CT
Popis výsledku anglicky
The investigation of the drug delivery into the lungs is essential for the effectiveness determination of their treatment. The numerical models are developed for the theoretical calculation of the particle deposition. The realistic human airway models were manufactured for the evaluation of the theoretical results. The overall drug accumulation is calculated but it is not possible to achieve the local deposition. The combined Positron Emission Tomography and X-ray Computed Tomography (PET/CT) imaging was applied for the local deposition analysis. The new algorithm for the precise identification of the individual section of the airway model in the CT data was created. PET/CT images were employed for the localization of deposited aerosol in the realistic model of the oral cavity and the following seven generation of the tracheobronchial tree. The realistic human airway model and the developed algorithm represent the new method for the precise local deposition of aerosol evaluation in human lungs.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
20303 - Thermodynamics
Návaznosti výsledku
Projekt
<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů