Insight into the interplay between metabolism of sarcosine and calmodulin-dependent signalling in prostate cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F18%3APU136049" target="_blank" >RIV/00216305:26620/18:PU136049 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/18:PU129761

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Insight into the interplay between metabolism of sarcosine and calmodulin-dependent signalling in prostate cells

Popis výsledku v původním jazyce

Prostate cancer (PCa) is the most common solid neoplasm w orldwide. Sarcosine, an intermediate and byproduct in glycine metabolism, represents a potential urinary biomarker exploitable for early PCa diagnosis. Concentration of sarcosine is substantially increased during PCa progression to its metastasis. Sarcosine has been shown to affect several genes involved in cell cycle and apoptosis. Nevertheless the mechanism responsible for these phenomena remains unknown. Calmodulin (CaM) is a ubiquitous calcium-binding protein. It is responsible for intracellular interactions connected with regulation of proliferation and malignity. CaM acts primarily through CaM-dependent signalling pathways connected into regulatory system important for cellular pathophysiology. CaM-dependent protein kinases are activated after ihe presence of CaM in neighbouring subunits activated by Ca2* ions. If CaM is accumulated in a sufficient amount, autophosphorylation occurs, leading to persistent activation of the enzyme. The ma

Název v anglickém jazyce

Insight into the interplay between metabolism of sarcosine and calmodulin-dependent signalling in prostate cells

Popis výsledku anglicky

Prostate cancer (PCa) is the most common solid neoplasm w orldwide. Sarcosine, an intermediate and byproduct in glycine metabolism, represents a potential urinary biomarker exploitable for early PCa diagnosis. Concentration of sarcosine is substantially increased during PCa progression to its metastasis. Sarcosine has been shown to affect several genes involved in cell cycle and apoptosis. Nevertheless the mechanism responsible for these phenomena remains unknown. Calmodulin (CaM) is a ubiquitous calcium-binding protein. It is responsible for intracellular interactions connected with regulation of proliferation and malignity. CaM acts primarily through CaM-dependent signalling pathways connected into regulatory system important for cellular pathophysiology. CaM-dependent protein kinases are activated after ihe presence of CaM in neighbouring subunits activated by Ca2* ions. If CaM is accumulated in a sufficient amount, autophosphorylation occurs, leading to persistent activation of the enzyme. The ma

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů