Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU132818" target="_blank" >RIV/00216305:26620/19:PU132818 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

Popis výsledku v původním jazyce

Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupl

Název v anglickém jazyce

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

Popis výsledku anglicky

Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupl

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů