Biogenic amines modified carbon quantum dots as antibacterial agent
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU134908" target="_blank" >RIV/00216305:26620/19:PU134908 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/19:43917127
Výsledek na webu
<a href="https://mendelnet.cz/artkey/mnt-201901-0108_Biogenic-amines-modified-carbon-quantum-dots-as-antibacterial-agent.php?back=/magno/mnt/2019/mn1.php?secid=4" target="_blank" >https://mendelnet.cz/artkey/mnt-201901-0108_Biogenic-amines-modified-carbon-quantum-dots-as-antibacterial-agent.php?back=/magno/mnt/2019/mn1.php?secid=4</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biogenic amines modified carbon quantum dots as antibacterial agent
Popis výsledku v původním jazyce
An alternative to conventional way is needed to treat multiple drug resistant bacteria. In this work, four different amine modified carbon quantum dots (CQDs) were obtained by microwave irradiation treatment. The four different biogenic amines (spermidine, putrescine, cadaverine, and histamine) as capping agent and citric acid as a carbon precursor were used. Prepared CQDs were evaluated for their antibacterial activity against three common pathogenic bacteria (Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus), and the growth curves were modeled. The CQDs showed a strong broad-spectrum antibacterial activity. The bactericidal activity was linked to their specific surface chemistry and caused bacterial death, which was due to the electrostatic interactions between protonated CQDs and the lipids of the bacterial cell membrane. The biocompatibility of CQDs was tested in HBL100 and HEK293 cell lines and low or absence of toxicity was indicated.
Název v anglickém jazyce
Biogenic amines modified carbon quantum dots as antibacterial agent
Popis výsledku anglicky
An alternative to conventional way is needed to treat multiple drug resistant bacteria. In this work, four different amine modified carbon quantum dots (CQDs) were obtained by microwave irradiation treatment. The four different biogenic amines (spermidine, putrescine, cadaverine, and histamine) as capping agent and citric acid as a carbon precursor were used. Prepared CQDs were evaluated for their antibacterial activity against three common pathogenic bacteria (Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus), and the growth curves were modeled. The CQDs showed a strong broad-spectrum antibacterial activity. The bactericidal activity was linked to their specific surface chemistry and caused bacterial death, which was due to the electrostatic interactions between protonated CQDs and the lipids of the bacterial cell membrane. The biocompatibility of CQDs was tested in HBL100 and HEK293 cell lines and low or absence of toxicity was indicated.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
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OECD FORD obor
10606 - Microbiology
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
MendelNet 2019 Proceedings of 26th International PhD Students Conference
ISBN
978-80-7509-688-3
ISSN
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e-ISSN
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Počet stran výsledku
5
Strana od-do
569-573
Název nakladatele
Mendel University in Brno
Místo vydání
Neuveden
Místo konání akce
Brno
Datum konání akce
6. 11. 2019
Typ akce podle státní příslušnosti
CST - Celostátní akce
Kód UT WoS článku
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