Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F20%3APU137012" target="_blank" >RIV/00216305:26620/20:PU137012 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/20:00116265

Výsledek na webu

<a href="https://www.mdpi.com/2073-4360/12/9/1877" target="_blank" >https://www.mdpi.com/2073-4360/12/9/1877</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym12091877" target="_blank" >10.3390/polym12091877</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

Popis výsledku v původním jazyce

Nanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.

Název v anglickém jazyce

Influence of Hydroxyapatite Nanoparticles and Surface Plasma Treatment on Bioactivity of Polycaprolactone Nanofibers

Popis výsledku anglicky

Nanofibers are well known as a beneficial type of structure for tissue engineering. As a result of the high acquisition cost of the natural polymers and their environmentally problematic treatment (toxic dissolution agents), artificial polymers seem to be the better choice for medical use. In the present study, polycaprolactone nano-sized fibrous structures were prepared by the electrospinning method. The impact of material morphology (random or parallelly oriented fibers versus continuous layer) and the presence of a fraction of hydroxyapatite nanoparticles on cell proliferation was tested. In addition, the effect of improving the material wettability by a low temperature argon discharge plasma treatment was evaluated, too. We have shown that both hydroxyapatite particles as well as plasma surface treatment are beneficial for the cell proliferation. The significant impact of both influences was evident during the first 48 h of the test: the hydroxyapatite particles in polycaprolactone fibers accelerated the proliferation by 10% compared to the control, and the plasma-treated ones enhanced proliferation by 30%.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymers

ISSN

2073-4360

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

1-16

Kód UT WoS článku

000579930900001

EID výsledku v databázi Scopus

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