Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU141829" target="_blank" >RIV/00216305:26620/21:PU141829 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14160/21:00119963

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s10570-021-04104-1.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s10570-021-04104-1.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10570-021-04104-1" target="_blank" >10.1007/s10570-021-04104-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

Popis výsledku v původním jazyce

Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.

Název v anglickém jazyce

Evaluation and comparison of structurally different cellulose-based hemostatic agents in a rat kidney model

Popis výsledku anglicky

Different topical hemostatic materials are used to achieve effective hemostasis. High hemostatic activity, biocompatibility, bioresorbability, and easy manipulation are to be expected in such a developed product. In the surgical world with these specific requirements, finding a proper hemostatic agent is very difficult. The study compared several materials of various construction properties, which were assessed for structural and related properties by morphological analyses and assessed in vivo for their efficiency and behaviour using a model of rat partial nephrectomy. New sodium salt of carboxymethyl cellulose (CMC) sponge with the lowest porosity and free swell absorptive capacity contained the highest amount of hydroxyl and carboxyl groups. Results revealed that this CMC material in the form of a bioresorbable sponge may ensure the necessary hemostatic effects, while also providing a positive influence on the reaction of the local tissue. The CMC material also needed significantly less time to achieve hemostasis (p < 0.001). Moreover, the sponge reached satisfactory results in the histopathological evaluation with the lowest destruction score and favorable healing reaction. This modified product proved itself to be a promising bioresorbable hemostat, which, according to its design, matches with its surgical applications. In general, the obtained data elucidated the dependency of the total effect on its structure and composition.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/TH04020540" target="_blank" >TH04020540: Nová bioaktivní hemostatika a krytí ran na bázi kolagenu a celulózy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CELLULOSE

ISSN

0969-0239

e-ISSN

1572-882X

Svazek periodika

14

Číslo periodika v rámci svazku

28

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

9369-9382

Kód UT WoS článku

000682466900002

EID výsledku v databázi Scopus

2-s2.0-85112668135