Questions about the role of P3HT nanoparticles in retinal stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU143382" target="_blank" >RIV/00216305:26620/21:PU143382 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41565-021-01044-6" target="_blank" >https://www.nature.com/articles/s41565-021-01044-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41565-021-01044-6" target="_blank" >10.1038/s41565-021-01044-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Questions about the role of P3HT nanoparticles in retinal stimulation

Popis výsledku v původním jazyce

Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.

Název v anglickém jazyce

Questions about the role of P3HT nanoparticles in retinal stimulation

Popis výsledku anglicky

Maya-Vetencourt et al.1 recently reported that poly[3-hexylthiophene] nanoparticles (P3HT NPs) injected in the subretinal space of the rat model of retinal dystrophy (the Royal College of Surgeons (RCS) model)) “mediate light-evoked stimulation of retinal neurons and persistently rescue visual function”. The article also reported that the light-evoked stimulation of retinal neurons is electrical in nature and is mediated by a capacitive coupling between the NPs and the cell membrane. To support these claims, the authors performed a series of experiments that demonstrated the P3HT NPs induced a cellular response in vitro, a retinal response ex vivo and rescue the visual functions in vivo. However, a number of inconsistencies throughout the article cast doubt on these results and their interpretation, as outlined below.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Nanotechnology (electronic)

ISSN

1748-3387

e-ISSN

1748-3395

Svazek periodika

16

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

1330-1332

Kód UT WoS článku

000728483500009

EID výsledku v databázi Scopus

2-s2.0-85121352533