A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU144729" target="_blank" >RIV/00216305:26620/22:PU144729 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.3144/expresspolymlett.2022.59" target="_blank" >https://doi.org/10.3144/expresspolymlett.2022.59</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3144/expresspolymlett.2022.59" target="_blank" >10.3144/expresspolymlett.2022.59</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Popis výsledku v původním jazyce

In recent times, autologous fat grafting has emerged as one of the most popular techniques for restoring volume depletion. Although the retention predictability of grafted fat has been improved, the quality of grafted tissue is still unsatisfactory. Unpredictable volume loss and low-fat survival is a major problem after application. Biodegradable PLGA-PEGPLGA (poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-pol (lactic-co-glycolic acid)) hydrogel delivery system enriched with stable fibroblast growth factor 2 (FGF2-STAB®), due to its properties, seems to be attractive material that will help to increase fat life. In this study, the mechanism of FGF2-STAB® release from an injectable thermosensitive and biodegradable PLGA-PEG-PLGA hydrogel was monitored. First-order kinetics were controlled mainly by decreasing the concentration of an active compound in the matrix and, at a later stage, by matrix degradation. Furthermore, the activity of the protein after release from the hydrogel matrix was studied. No loss of FGF2-STAB® activity in the dynamic system after 14 days has been detected. The development of such a drug delivery system appears promising for further use in reconstructive medicine e.g., in mixing with fat graft being the subject of current research.

Název v anglickém jazyce

A novel approach in control release monitoring of protein-based bioactive substances from injectable PLGA-PEG-PLGA hydrogel

Popis výsledku anglicky

In recent times, autologous fat grafting has emerged as one of the most popular techniques for restoring volume depletion. Although the retention predictability of grafted fat has been improved, the quality of grafted tissue is still unsatisfactory. Unpredictable volume loss and low-fat survival is a major problem after application. Biodegradable PLGA-PEGPLGA (poly(lactic-co-glycolic acid)-b-poly(ethylene glycol)-b-pol (lactic-co-glycolic acid)) hydrogel delivery system enriched with stable fibroblast growth factor 2 (FGF2-STAB®), due to its properties, seems to be attractive material that will help to increase fat life. In this study, the mechanism of FGF2-STAB® release from an injectable thermosensitive and biodegradable PLGA-PEG-PLGA hydrogel was monitored. First-order kinetics were controlled mainly by decreasing the concentration of an active compound in the matrix and, at a later stage, by matrix degradation. Furthermore, the activity of the protein after release from the hydrogel matrix was studied. No loss of FGF2-STAB® activity in the dynamic system after 14 days has been detected. The development of such a drug delivery system appears promising for further use in reconstructive medicine e.g., in mixing with fat graft being the subject of current research.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/EF19_073%2F0016948" target="_blank" >EF19_073/0016948: Kvalitní interní granty VUT</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EXPRESS POLYM LETT

ISSN

1788-618X

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

14

Strana od-do

798-811

Kód UT WoS článku

000812326600003

EID výsledku v databázi Scopus

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