An investigation on the multiple roles of CeO2 nanoparticle in electrochemical sensing: Biomimetic activity and electron acceptor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU148293" target="_blank" >RIV/00216305:26620/23:PU148293 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/23:43923176

Výsledek na webu

<a href="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1572665723001613" target="_blank" >https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S1572665723001613</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2023.117301" target="_blank" >10.1016/j.jelechem.2023.117301</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An investigation on the multiple roles of CeO2 nanoparticle in electrochemical sensing: Biomimetic activity and electron acceptor

Popis výsledku v původním jazyce

Nanomaterials with enzyme-like activity (nanozymes) are known to be suitable alternatives for natural enzymes tolerating unfavorable pH and temperature conditions. The enzyme-like activity of CeO2 nanoparti-cles was already reported and used in electrochemical sensing, where the peroxidase or oxidase-like activities of CeO2 NPs are mainly used. This work aims to justify the role/s that CeO2 may play in electrochemical sens -ing as a nanozyme and acts as a mediator. To this end, a reduced graphene oxide-CeO2 was prepared and used in two electrochemical sensing configurations. In first configuration, H2O2 reduction was catalyzed at the glassy carbon electrode modified with the rGO-CeO2 nanocomposite (rGO-CeO2 NC). The reduction current obtained upon the presence of H2O2 was attributed to a mediator role having a linear range of 100.0-800.0 mu mol L-1 with a limit of detection (LOD) and limit of quantification (LOQ) of 15.9 mu mol L-1 and 52.9 mu mol L-1, respectively. In another configuration, glucose oxidase was used as a model enzyme with the rGO-CeO2 NC. The oxidation signal obtained upon adding glucose was attributed to the electron-accepting role of the CeO2 NPs. The analytical figures of merit obtained for both configurations indicated their high sen-sitivity, selectivity, and reproducibility. The linear detection range for the nanozyme-enzyme cascade system was 100.0-800.0 mu mol L-1 with a LOD and LOQ of 18.7 mu mol L-1 and 62.3 mu mol L-1, respectively. Moreover, the flow injection analysis was enabled due to the short response time in analysis with the prepared sensor. The possibility for applying the developed nanozyme in nanozyme-enzyme cascade system in clinical and food analysis for determination of glucose was verified by studying the interference of various compounds similar to glucose in structure and typical drugs taken by diabetic patients.

Název v anglickém jazyce

An investigation on the multiple roles of CeO2 nanoparticle in electrochemical sensing: Biomimetic activity and electron acceptor

Popis výsledku anglicky

Nanomaterials with enzyme-like activity (nanozymes) are known to be suitable alternatives for natural enzymes tolerating unfavorable pH and temperature conditions. The enzyme-like activity of CeO2 nanoparti-cles was already reported and used in electrochemical sensing, where the peroxidase or oxidase-like activities of CeO2 NPs are mainly used. This work aims to justify the role/s that CeO2 may play in electrochemical sens -ing as a nanozyme and acts as a mediator. To this end, a reduced graphene oxide-CeO2 was prepared and used in two electrochemical sensing configurations. In first configuration, H2O2 reduction was catalyzed at the glassy carbon electrode modified with the rGO-CeO2 nanocomposite (rGO-CeO2 NC). The reduction current obtained upon the presence of H2O2 was attributed to a mediator role having a linear range of 100.0-800.0 mu mol L-1 with a limit of detection (LOD) and limit of quantification (LOQ) of 15.9 mu mol L-1 and 52.9 mu mol L-1, respectively. In another configuration, glucose oxidase was used as a model enzyme with the rGO-CeO2 NC. The oxidation signal obtained upon adding glucose was attributed to the electron-accepting role of the CeO2 NPs. The analytical figures of merit obtained for both configurations indicated their high sen-sitivity, selectivity, and reproducibility. The linear detection range for the nanozyme-enzyme cascade system was 100.0-800.0 mu mol L-1 with a LOD and LOQ of 18.7 mu mol L-1 and 62.3 mu mol L-1, respectively. Moreover, the flow injection analysis was enabled due to the short response time in analysis with the prepared sensor. The possibility for applying the developed nanozyme in nanozyme-enzyme cascade system in clinical and food analysis for determination of glucose was verified by studying the interference of various compounds similar to glucose in structure and typical drugs taken by diabetic patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ELECTROANALYTICAL CHEMISTRY

ISSN

1572-6657

e-ISSN

1873-2569

Svazek periodika

935

Číslo periodika v rámci svazku

117301

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000956549100001

EID výsledku v databázi Scopus

2-s2.0-85150076394