Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU150715" target="_blank" >RIV/00216305:26620/23:PU150715 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/advs.202300473" target="_blank" >10.1002/advs.202300473</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Popis výsledku v původním jazyce

Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image

Název v anglickém jazyce

Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Popis výsledku anglicky

Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Science

ISSN

2198-3844

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

31

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

„“-„“

Kód UT WoS článku

001057823100001

EID výsledku v databázi Scopus

2-s2.0-85169437223